Oxidant stress and endothelial cell dysfunction.

By H. Lum, K. Roebuck. American Journal of Physiology - Cell Physiology, 2001

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The role of oxidative stress in atherosclerosis. (2009, background): “apoptosis of endothelial cells, the oxidation of lipids, the activation of metalloproteinases and the alteration of vasomotor activity.(4,5) This hypothesis raises questions about the understanding of the path-”
Role of inflammatory mediators in the pathophysiology of acute respiratory distress syndrome (2004, background): “Several mechanisms are responsible for oxidant-mediated endothelial barrier dysfunction, which include activation of pathways leading to increases in intracellular ionized calcium concentration; activation of the signalling protein, myosin light chain kinase; activation of the signalling enzyme, pro”
Endothelial dysfunction in diabetes mellitus (2007, neutral): “Specifi cally, oxidative stress increases vascular endothelial permeability and promotes leukocyte adhesion, which is coupled with alterations in endothelial signal transduction and redox-regulated transcription factors (Hazel et al 2001).”
NADPH Oxidases in Cardiovascular Health and Disease (2006, neutral): “Furthermore, hypertrophy of cultured VSMCs following stimulation by either thrombin or serum was found to be p47 phox -dependent but did not require Nox2 suggesting the involvement of the Nox1 isoform (22).”