The Piwi-piRNA Pathway Provides an Adaptive Defense in the Transposon Arms Race

By Alexei Aravin, Gregory J. Hannon, J. Brennecke. Science, 2007

1,133 citations recorded by the source corpus.

Subfields: Molecular Biology, Plant Science

View Paper: https://www.semanticscholar.org/paper/b0bcd68ac093c0f85710b95c2468a9a9492f83ac

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Molecular Biology

In Plant Science

Citations in the corpus

PIWI-interacting small RNAs: the vanguard of genome defence (2011, background): “The first piRNAs described in mammals — which were named pachytene piRNAs because they are first expressed during the pachytene stage of meiosis — do not target transposon”
Distinguishing protein-coding and noncoding genes in the human genome (2007, background): “In post-pubescent mammalian testis, piRNAs arise from dense strand-biased clusters whose biogenesis and functions remain largely unknown, although roles in transposon defense are supported for piRNAs that are expressed in germ cell precursors earlier in development (Aravin et al. 2007a).”
Specialized piRNA Pathways Act in Germline and Somatic Tissues of the Drosophila Ovary (2009, background): “Signatures of the ping-pong cycle are conserved throughout animals, suggesting that it is a fundamental property of the piRNA pathway (Aravin et al., 2007b; Houwing et al., 2007; Murchison et al., 2008).”
Long Noncoding RNA MALAT1 Controls Cell Cycle Progression by Regulating the Expression of Oncogenic Transcription Factor B-MYB (2013, background): “Small ncRNAs such as microRNAs regulate the expression of target genes at the level of translation or mRNA stability, whereas piwi-interacting RNAs (piRNA) have been linked to transcriptional gene silencing of retrotransposons and other repeat-containing genetic elements [5,6,7,8].”
Epigenetic reprogramming and small RNA silencing of transposable elements in pollen (2009, neutral): “piRNAs arise from repetitive DNA in a Dicer-independent mechanism (Aravin et al., 2007; Grivna et al., 2006; Lau et al., 2006).”
Establishing, maintaining and modifying DNA methylation patterns in plants and animals (2010, background): “melanogaster , piRNAs bound by the Piwi clade of Agos guide cleavage of transposon transcripts, which results in post-transcriptional gene silencin”
A piRNA pathway primed by individual transposons is linked to de novo DNA methylation in mice (2008, background): “The Ping-Pong Cycle in Prenatal piRNAs Two different mechanisms, primary processing and ping-pong amplification, have been proposed to generate piRNAs (Brennecke et al., 2007; reviewed in Aravin et al., 2007a ).”