Antibiotic resistance is ancient

By Vanessa M. D’Costa, Christine E. King, Lindsay Kalan, M. Morar, Wilson W. L. Sung, Carsten Schwarz, D. Froese, G. Zazula, F. Calmels, R. Debruyne and 3 more. Nature, 2011

2,414 citations recorded by the source corpus.

Subfields: Clinical Biochemistry, Ecology, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/b07bae86dcd40e74674f97c0419d6c2543ecd7c0

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Clinical Biochemistry

In Ecology

In Molecular Biology

Citations in the corpus

Antibiotic Pollution in the Environment: From Microbial Ecology to Public Policy (2019, background): “Likewise, resistance genes have been found in 30,000- to 5000-year-old permafrost samples, though a clear increase of the abundance of resistance genes in current samples compared to ancient ones is evident [40,41].”
Do manure-borne or indigenous soil microorganisms influence the spread of antibiotic resistance genes in manured soil? (2017, background): “mented to be ancient and can occur naturally (D'Costa et al., 2011), even if various antibiotics had not been produced (Davelos et al.”
The Rising Tide of Antimicrobial Resistance in Aquaculture: Sources, Sinks and Solutions (2017, background): “Antibiotic resistance is an ancient process and predates any clinical antibiotic usage [23], however, the increase of extensive drug resistant (XDR) and multidrug drug resistant (MDR) strains is a cause of immense concern.”
Bacteria Antibiotic Resistance: New Challenges and Opportunities for Implant-Associated Orthopaedic Infections (2017, background): “Furthermore, genes encoding resistance to b-lactam, tetracycline, and glycopeptide antibiotics have been identified from the 30,000-year-old DNA found in Beringian permafrost sediments.(30)”
Antibiotic-Induced Changes in the Intestinal Microbiota and Disease. (2016, background): “Surprisingly, both the DNA sequences and the structural organization within AR operons identified in these ancient bacteria were found to exhibit high similarity to those carried by currently circulating microbes [95].”
Metagenomic and network analysis reveal wide distribution and co-occurrence of environmental antibiotic resistance genes (2015, background): “…although vancomycin resistance genes have also been found in permafrost sediments, which were never affected by the anthropogenic activities before (D’Costa et al., 2011), and the average abundance of vancomycin resistance genes in the samples of this study was relatively low (1.6 × 10− 5–1.8 ×10−…”
Environmental factors influencing the development and spread of antibiotic resistance (2017, neutral): “…almost ubiquitous presence of resistance genes in a vast range of environments (Allen et al. 2009; Sommer, Dantas and Church 2009; Lang et al. 2010; D’Costa et al. 2011; Martiny et al. 2011; Forsberg et al. 2012; Segawa et al. 2012; Munck et al. 2015; Pal et al. 2016) further supports that this is…”
Antimicrobial Resistance in Bacteria: Mechanisms, Evolution, and Persistence (2019, background): “On the other hand, the molecular pathways behind the emergence of antimicrobial resistance in bacteria have been present since ancient times (Dcosta et al. 2011).”
Co-selection of antibiotic and heavy metal resistance in freshwater bacteria (2016, methodology): “Moreover many reports hint to a non-negligible amount of ARGs even in areas that are not directly impacted, such as permafrost and caves (D’Costa et al., 2011; Bhullar et al., 2012; Segawa et al., 2013).”