Regulation of the innate and adaptive immune responses by Stat-3 signaling in tumor cells

By Tianhong Wang, G. Niu, M. Kortylewski, L. Burdelya, K. Shain, Shumin M. Zhang, R. Bhattacharya, D. Gabrilovich, R. Heller, D. Coppola and 4 more. Nature Medicine, 2004

1,211 citations recorded by the source corpus.

Subfields: Cancer Research, Immunology, Oncology

View Paper: https://www.semanticscholar.org/paper/b050c9c5e4d3887231769329968e8a6c1125c157

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Citations in the corpus

The BRAF–MAPK signaling pathway is essential for cancer-immune evasion in human melanoma cells (2006, background): “Because activated STAT3 signaling has been determined to result in immune evasion from cancer through the production of various factors including VEGF (8, 9), we investigated the relationship between the MAPK and the STAT3 pathways concerning the production of immunosuppressive factors in the A375 m”
Immunosuppressive strategies that are mediated by tumor cells. (2007, background): “In very elegant experiments, Wang and colleagues demonstrated that oncogenic signaling pathways, such as Stat3, can actively modulate tumor cell evasion of immune responses by inhibiting the production of proinflammatory danger signals (33).”
Coordinated regulation of myeloid cells by tumours (2012, background): “Early studies identified STAT3 as a crucial regulator of DC and macrophage defect”
STATs in cancer inflammation and immunity: a leading role for STAT3 (2009, neutral): “Importantly, the persistent activation of STAT3 intrinsic to tumour cells is transmitted to stromal inflammatory cells in the tumour microenvironmen”
Inflammation, a Key Event in Cancer Development (2006, background): “NF-nB Mediate inflammation progress, promoting chronic inflammation (134, 135, 142) Promote the production of mutagenic reactive oxygen species (128) Protect transformed cells from apoptosis (157, 158) Promote tumor invasion and metastasis (5, 160) Feedback loop between proinflammatory cytokines (13”
Conditional ablation of Stat3 or Socs3 discloses a dual role for reactive astrocytes after spinal cord injury (2006, background): “Stat3 is a principal mediator in a variety of biological processe”
Cancer-related inflammation (2008, background): “The activation of STAT3 in tumour cells has also been shown to increase the capacity of tumours to evade the immune system, by inhibiting the maturation of dendritic cell”
IL-6 and STAT3 are required for survival of intestinal epithelial cells and development of colitis associated cancer (2009, background): “Although Stat3 has been known as an oncogenic transcription factor (Bromberg et al., 1999; Sriuranpong et al., 2003; Wang et al., 2004; Yu et al., 2007), it has only recently been proven to be critical for tumor initiation and growth in vivo in a model of skin cancer (Chan et al., 2004; Kataoka et…”