Conditional inactivation of FGF receptor 2 reveals an essential role for FGF signaling in the regulation of osteoblast function and bone growth
By Kai Yu, Jingsong Xu, Zhonghao Liu, Dražen Šošić, J. Shao, E. Olson, D. Towler, D. Ornitz. Development, 2003
642 citations recorded by the source corpus.
Subfields: Genetics, Molecular Biology
View Paper: https://www.semanticscholar.org/paper/a401be7572e9f6a0f12579accf545001811e9a0c
How researchers see this paper
The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.
In Genetics
In Molecular Biology
Citations in the corpus
- Development of the endochondral skeleton. (2013, background): “Although conditional inactivation of Fgfr2 in mesenchymal precursor cells (with Dermo1-Cre)4 does not cause a major effect on cartilage (Yu et al. 2003), inactivation of both FGFRs 1 and 2 in the limb bud mesenchyme (with Prx1-Cre) results in smaller skeletal elements.”
- Building strong bones: molecular regulation of the osteoblast lineage (2011, background): “By contrast, FGFR2 promotes the proliferation of preosteoblasts and the function of mature osteoblast”
- FGF/FGFR signaling in health and disease (2020, background): “Yu et al.(193) found that conditional deletion of FGFR2 in mesenchyme can lead to skeletal dwarfism and decreased bone mineral density with dramatically disturbed proliferation of osteoprogenitors and anabolic function of mature osteoblasts in mice.”
- Fibroblast growth factor signalling: from development to cancer (2010, background): “This has been most clearly demonstrated in the development of endochondral and membranous bone, in which mouse models have shown that FGFR3 and FGFR2 can negatively regulate proliferation and positively drive differentiatio”