Multiple sclerosis: an immune or neurodegenerative disorder?

By B. Trapp, K. Nave. Annual Review of Neuroscience, 2008

1,750 citations recorded by the source corpus.

Subfields: Neurology, Pathology and Forensic Medicine

View Paper: https://www.semanticscholar.org/paper/af27fb8c4623515417103c863338edb056b81f54

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In Neurology

In Pathology and Forensic Medicine

Citations in the corpus

CNS-Resident Glial Progenitor/Stem Cells Produce Schwann Cells as well as Oligodendrocytes during Repair of CNS Demyelination (2010, neutral): “Failure of remyelination in progressive MS is associated with secondary axonal loss, which leads to the untreatable clinical deterioration that often characterizes late-stage MS (Trapp and Nave, 2008).”
Dysregulation of the Wnt pathway inhibits timely myelination and remyelination in the mammalian CNS. (2009, background): “…be extensive in MS (Patrikios et al. 2006; Patani et al. 2007), it is an inconsistent event, and the accumulated load of lesions that fail to remyelinate in a timely manner contributes to irreversible axon loss and progressive neurological deterioration (Frohman et al. 2006; Trapp and Nave 2008).”
Remyelination in the CNS: from biology to therapy (2008, background): “This is thought to be the major cause of this chronic progressive diseas”
Mechanisms Underlying Inflammation in Neurodegeneration (2010, neutral): “The deposition of antibodies and complement around demyelinated lesions (Frohman et al., 2006) and axonal degeneration in the progression phase of MS have also been observed (Trapp and Nave, 2008).”
Axon-glial signaling and the glial support of axon function. (2008, background): “The enormous plasticity of the brain may be able to mask a slowly progressive degeneration of the subcortical axons for a long time, and a substantial axonal loss may remain clinically silent in MS patients (Trapp & Nave 2008).”
A reversible form of axon damage in experimental autoimmune encephalomyelitis and multiple sclerosis (2011, background): “2324" language="eng" relation="no"> In multiple sclerosis, a common inflammatory disease of the central nervous system, immune-mediated axon damage is responsible for permanent neurological deficit”
Pathogenic Mechanisms Associated With Different Clinical Courses of Multiple Sclerosis (2019, background): “In this situation PPMS could reflect the primary disease process of MS and the other courses (RRMS and SPMS) are those, modified by an inflammatory reaction (3).”
Sialic acids in the brain: gangliosides and polysialic acid in nervous system development, stability, disease, and regeneration. (2014, background): “Myelin nurtures the axons it enwraps, and when axon-myelin interactions are compromised, axons suffer (492).”