TYPE I INTERFERONS (/) IN IMMUNITY AND AUTOIMMUNITY

By Interferons, A. Theofilopoulos, R. Baccala, B. Beutler, D. Kono. 2005

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Type I interferon inhibits interleukin-1 production and inflammasome activation. (2011, background): “Particular attention has been paid to the anti-inflammatory effects exerted by type I IFN, demonstrated by two lines of evidence (Billiau, 2006; Theofilopoulos et al., 2005).”
Parsing the interferon transcriptional network and its disease associations (2016, positive): “In addition, the interferon transcriptional signature is found elevated in blood cells in many diseases (Theofilopoulos et al., 2005; Forster, 2012), including bacterial or parasitic infections as might be expected (Berry et al., 2010) but also a range of auto-inflammatory disease like Systemic…”
A Toll-like receptor–independent antiviral response induced by double-stranded B-form DNA (2006, background): “Other less-convincing data have suggested that TLRs may also be important in autoimmune disease”
Toll-like receptors in systemic autoimmune disease (2006, background): “There are 13 subtypes of IFNα, and these constitute a highly pleiotropic cytokine family with diverse biological functions that are usually associated with immune responses to viral infection (reviewed in Ref”
Trex1 prevents cell-intrinsic initiation of autoimmunity (2008, positive): “Detection of intracellular DNA by the ISD pathway activates potent type I IFN production, and elevated type I IFNs are a hallmark of AGS and lupus (Crow et al., 2003; Pascual et al., 2006; Theofilopoulos et al., 2005).”