Reciprocal Binding of PARP-1 and Histone H1 at Promoters Specifies Transcriptional Outcomes

By Raga Krishnakumar, Matthew J. Gamble, Kristine M. Frizzell, Jhoanna G. Berrocal, Miltiadis Kininis, W. Kraus. 2008

430 citations recorded by the source corpus.

Subfields: Molecular Biology, Oncology

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Molecular Biology

1. W. Kraus
2. Raga Krishnakumar
3. Xin Luo
4. Michael J Hendzel

In Oncology

1. W. Kraus
2. Raga Krishnakumar
3. Rebecca Gupte
4. Ziying Liu
5. Xin Luo
6. Michael J Hendzel

Citations in the corpus

• The expanding field of poly(ADP-ribosyl)ation reactions. ‘Protein Modifications: Beyond the Usual Suspects' Review Series (2008, background): “Nature 451: 81–85 amé Jc, Spenlehauer c, de Murcia g (2004) the parp superfamily. Bioessays 26: 882–893 Berger F, Lau c, ziegler M (2007) regulation of poly(aDp-ribose) polymerase 1 activity by the phosphorylation state of the nuclear NaD biosynthetic enzyme NMN adenylyl transferase 1.”
• On PAR with PARP: cellular stress signaling through poly(ADP-ribose) and PARP-1. (2012, background): “PARP-1 localizes to the promoters of essentially all actively transcribed genes (and perhaps all open regions of chromatin) (Krishnakumar et al. 2008; Krishnakumar and Kraus 2010b), but affects the expression of only a subset of the genes to which it binds (Frizzell et al.”
• PARPs and ADP-ribosylation: recent advances linking molecular functions to biological outcomes (2017, background): “This decondensation could be due to the ADP-ribosylation of histoneH1 by PARP-1 or competitive displacement of histone H1 from nucleosomes by PARP-1 (Kim et al. 2004; Krishnakumar et al. 2008).”
• The PARP Side of the Nucleus: Molecular Actions, Physiological Outcomes, and Clinical Targets (2010, positive): “PARP-1 also binds to chromatin outside of promoter regions, including enhancers (Krishnakumar et al., 2008).”
• PARP inhibition: PARP1 and beyond (2010, background): “Chromatin immunoprecipitation experiments demonstrate that PARP1 is generally associated with actively transcribed genes, at which it is postulated to regulate histone H1 binding to chromati”