Alpha-synuclein, especially the Parkinson's disease-associated mutants, forms pore-like annular and tubular protofibrils.

By H. Lashuel, B. Petre, J. Wall, M. Simon, R. Nowak, Thomas Walz, P. Lansbury. Journal of Molecular Biology, 2002

828 citations recorded by the source corpus.

Subfields: Biomaterials, Neurology

View Paper: https://www.semanticscholar.org/paper/aee76f04984b7b45f8eaa14025c3b2f2a00b3eae

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In Biomaterials

1. Christopher M. Dobson
2. Tuomas P. J. Knowles

In Neurology

1. S. Przedborski
2. E. Masliah
3. Christopher M. Dobson
4. A. Abramov
5. W. Dauer
6. Valina L. Dawson
7. T. Dawson

Citations in the corpus

• Exosomal cell-to-cell transmission of alpha synuclein oligomers (2012, background): “The main component of Lewy bodies and Lewy neurites are fibrillar aggregates of αsyn [1] but a growing body of evidence suggests that prefibrillar oligomers of αsyn are key contributors in the progression of Parkinson's disease [9-15].”
• Mitochondrial Dysfunction in Parkinson's Disease (2011, background): “[139] H.”
• Parkinson's Disease Mechanisms and Models (2003, background): “…this view and the association of -synuclein with synaptic vesicles,presynaptic nerve terminals in close association with synaptic vesicles (Maroteaux et al., 1988; George et al., protofibrils may cause toxicity by permeabilizing synaptic vesicles (Volles et al., 2001; Lashuel et al., 2002),1995).”
• Neuropathological alterations in Alzheimer disease. (2011, background): “Several lines of investigation support the notion that oligomeric forms of Ab and asynuclein, rather than the polymers and fibrils associated with plaques and LBs, accumulate in the neuronal membranes and lead to the characteristic synaptic pathology (Lambert et al. 1998; Conway et al. 2000; Lashuel”
• Different Species of α-Synuclein Oligomers Induce Calcium Influx and Seeding (2007, background): “They demonstrated with synthetic vesicles a pore-forming mechanism of -syn protofibrils (Volles et al., 2001; Volles and Lansbury, 2002; Lashuel et al., 2002a).”
• Direct Observation of the Interconversion of Normal and Toxic Forms of α-Synuclein (2012, methodology): “A variety of distinct morphologies of aS oligomers have been observed using imaging techniques, notably, atomic force microscopy or transmission electron microscopy (see, e.g., Conway et al., 2000; Ding et al., 2002; Lashuel et al., 2002; Hoyer et al., 2004).”