The roles of TLRs, RLRs and NLRs in pathogen recognition.

By Taro Kawai, Shizuo Akira. International Immunology, 2009

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Membrane Vesicle Release in Bacteria, Eukaryotes, and Archaea: a Conserved yet Underappreciated Aspect of Microbial Life (2012, neutral): “downstream NF-kB-dependent inflammatory responses (35, 36).”
Immunomodulatory functions of type I interferons (2012, background): “However, it became evident that TLR-deficient animals can still produce type I IFNs in response to RNA and DNA ligand”
Immune signaling by RIG-I-like receptors (2011, background): “Signaling through the IPS-1-associated TRADD-FADDRIP1 complex results in the recruitment of TANK and NEMO to the IPS-1 signalosome to facilitate IRF3 and IRF7 activation by TBK1, IKKa-IKKb-dependent activation of NF-kB, and IFN production (Kawai and Akira, 2009).”
Impact of heat stress and nutritional interventions on poultry production (2018, background): “Tolllike receptors (TLRs) have the capacity for PRRs recognition for a wide range of pathogen-associated molecular patterns (PAMPs), and likewise play a central role in initiating innate immune response of specific signalling (Kawai and Akira, 2009).”
Innate immunity in the central nervous system. (2012, positive): “These pathways were linked by the discovery that cooperative signaling through TLRs and NLRs culminated in secretion of IL-1 family cytokines (32).”