A genomic storm in critically injured humans

By Wenzhong Xiao, M. Mindrinos, Junhee Seok, J. Cuschieri, A. Cuenca, H. Gao, Douglas L. Hayden, Laura V. Hennessy, Ernest E. Moore, J. Minei and 30 more. Journal of Experimental Medicine, 2011

1,103 citations recorded by the source corpus.

Critical injury in humans induces a genomic storm with simultaneous changes in expression of innate and adaptive immunity genes.

Subfields: Epidemiology, Immunology, Pulmonary and Respiratory Medicine

View Paper: https://www.semanticscholar.org/paper/aebbe77b60494985c1ccb04c7057ba9efb5192bf

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

1. Junhee Seok
2. H. Warren
3. A. Cuenca
4. M. Jeschke
5. Lori F. Gentile
6. M. Mindrinos
7. L. Moldawer
8. H. Baker

Citations in the corpus

• Persistent inflammation and immunosuppression: A common syndrome and new horizon for surgical intensive care (2012, background): “2B).(19) Glue Grant participants found modest compliance with agreed evidence-based SOPs to be associated with dramatic reduction of overall mortality rate from 22% before to 11% after SOP implementation.”
• Genomic responses in mouse models poorly mimic human inflammatory diseases (2013, methodology): “These datasets include genome-wide expression analysis on white blood cells obtained from serial blood draws in 167 patients up to 28 d after severe blunt trauma (15), 244 patients up to 1 y after burn injury, and 4 healthy humans for 24 h after administration of low-dose bacterial endotoxin (14) an”