Hypothesis for potential pathogenesis of SARS-CoV-2 infection–a review of immune changes in patients with viral pneumonia
By Ling Lin, Lianfeng Lu, W. Cao, Taisheng Li. Emerging Microbes and Infections, 2020
846 citations recorded by the source corpus.
ABSTRACT Coronavirus disease 2019 (COVID-19) is an infectious disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) with droplets and contact as the main means of transmission. Since the first case appeared in Wuhan, China, in December 2019, the outbreak has gradually spread nationwide. Up to now, according to official data released by the Chinese health commission, the number of newly diagnosed patients has been declining, and the epidemic is gradually being controlled. Although most patients have mild symptoms and good prognosis after infection, some patients developed severe and die from multiple organ complications. The pathogenesis of SARS-CoV-2 infection in humans remains unclear. Immune function is a strong defense against invasive pathogens and there is currently no specific antiviral drug against the virus. This article reviews the immunological changes of coronaviruses like SARS, MERS and other viral pneumonia similar to SARS-CoV-2. Combined with the published literature, the potential pathogenesis of COVID-19 is inferred, and the treatment recommendations for giving high-doses intravenous immunoglobulin and low-molecular-weight heparin anticoagulant therapy to severe type patients are proposed.
Subfields: Infectious Diseases, Neurology
View Paper: https://www.semanticscholar.org/paper/5183033ead766f9d27a6f7267470d5524ec65e27
How researchers see this paper
The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.
In Infectious Diseases
In Neurology
Citations in the corpus
- Coronavirus Diseases (COVID-19) Current Status and Future Perspectives: A Narrative Review (2020, background): “In positive patients with a D-Dimer value four times higher than the normal limit, and without anticoagulant contraindications, an anticoagulation therapy is recommended [56].”
- Immune Response, Inflammation, and the Clinical Spectrum of COVID-19 (2020, background): “Finally, it is important to remember what many investigators of SARS and MERS have written in their publications, long before the emergency of COVID-19 pandemics: what will be learned from this pandemic must be used to prevent future coronavirus epidemics.”
- SARS-CoV-2 infection: The role of cytokines in COVID-19 disease (2020, neutral): “[185] Literature review To clarify the pathogenesis of SARS-CoV-2 and compare it”
- Aging in COVID-19: Vulnerability, immunity and intervention (2020, positive): “elevated in COVID-19 patients, and such elevation is associated with disease severity and progression (Lagunas-Rangel and Chavez-Valencia, 2020; Lin et al., 2020; Yang et al., 2020).”
- Cytokine storm in COVID-19: pathogenesis and overview of anti-inflammatory agents used in treatment (2020, background): “On the other hand, ischemic changes in the fingers and toes mimicking vasculitis have been reported in patients with severe COVID-19 [13].”
- Lymphopenia in severe coronavirus disease-2019 (COVID-19): systematic review and meta-analysis (2020, background): “Our understanding of the pathogenesis of lymphocyte reduction in COVID-19 might possibly be enlightened by studies of other similar beta-CoV infection, including severe acute respiratory syndrome (SARS)-CoV and Middle East respiratory syndrome (MERS)-CoV [34].”