Decreased gut microbiota diversity, delayed Bacteroidetes colonisation and reduced Th1 responses in infants delivered by Caesarean section

By Hedvig E. Jakobsson, T. Abrahamsson, M. Jenmalm, Keith W Harris, Christopher Quince, Cecilia Jernberg, B. Björkstén, L. Engstrand, Anders F. Andersson. Gut, 2013

943 citations recorded by the source corpus.

Subfields: Microbiology, Molecular Biology, Nutrition and Dietetics

View Paper: https://www.semanticscholar.org/paper/ae081edc60a62b1b1d542167dbe716ce7c5ec9ff

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Microbiology

B. B. Finlay

In Molecular Biology

In Nutrition and Dietetics

Citations in the corpus

The infant microbiome development: mom matters (2014, positive): “in microbial composition introduced by delivery mode persist in the infant, differences in specific microbial species have been observed between C-section- and vaginally delivered babies after 1 month [81], 2 years [82], and even 7 years [83] of life.”
The Intestinal Microbiome in Early Life: Health and Disease (2014, background): “The authors hypothesize that this drop in diversity may be due to delayed colonization of the gut by Bacteroidetes, as some C-section delivered infants showed no signs of Bacteroidetes colonization until 1 year of age (60).”
The First Microbial Colonizers of the Human Gut: Composition, Activities, and Health Implications of the Infant Gut Microbiota (2017, background): “Infants born by C-section also show a reduced complexity of the gut microbiota and are less often colonized by microorganisms such as Bifidobacterium and Bacteroides, while being more frequently colonized by members of Clostridium sensu stricto (cluster I) and Clostridium difficile (70, 71, 74–79).”
Antibiotics, birth mode, and diet shape microbiome maturation during early life (2016, result): “Although several studies have noted decreased phylum Bacteroidetes in cesarean-delivered infants (45, 46), we now show that this effect persists throughout the first year of life and is associated with an altered metagenomic landscape in the gut, consistent with the findings of Yassour et al.”
The gut microbiome: Relationships with disease and opportunities for therapy (2018, background): “Many of these exposures are known to shape the nascent gut microbiome, including cesarean birth (Dominguez-Bello et al., 2010; Jakobsson et al., 2014; Bäckhed et al., 2015; Stokholm et al., 2016; Chu et al., 2017), antimicrobial administration (Johnson et al.”
The human microbiome (2017, neutral): “тип микробиоты кишечника, характеризующийся высокими концентрациями представителей рода Bifidobacterium [3], что в значительной степени определяется содержа-”
DegePrime, a Program for Degenerate Primer Design for Broad-Taxonomic-Range PCR in Microbial Ecology Studies (2014, methodology): “We used DegePrime earlier to design a primer pair, 341F-805R, for ampliﬁcation of the V3-V4 region, which has been used in 454-based studies on a range of environments (11–16).”
Natural history of the infant gut microbiome and impact of antibiotic treatments on strain-level diversity and stability (2015, background): “Previous studies have suggested that children born by cesarean section have less diverse gut microbiomes (30, 38); however, we found decreased a-diversity in low-Bacteroides children irrespective of mode of delivery.”
The composition of the gut microbiota throughout life, with an emphasis on early life (2015, background): “In recent reports, it has also been shown that microbiota diversity is decreased with C-section, compared to vaginal delivery (35).”