Draft Genome of the Filarial Nematode Parasite Brugia malayi
By E. Ghedin, Shiliang Wang, D. Spiro, E. Caler, Qi Zhao, J. Crabtree, Jonathan E. Allen, Arthur L. Delcher, David B. Guiliano, Diego Miranda-Saavedra and 61 more. Science, 2007
661 citations recorded by the source corpus.
Parasitic nematodes that cause elephantiasis and river blindness threaten hundreds of millions of people in the developing world. We have sequenced the ∼90 megabase (Mb) genome of the human filarial parasite Brugia malayi and predict ∼11,500 protein coding genes in 71 Mb of robustly assembled sequence. Comparative analysis with the free-living, model nematode Caenorhabditis elegans revealed that, despite these genes having maintained little conservation of local synteny during ∼350 million years of evolution, they largely remain in linkage on chromosomal units. More than 100 conserved operons were identified. Analysis of the predicted proteome provides evidence for adaptations of B. malayi to niches in its human and vector hosts and insights into the molecular basis of a mutualistic relationship with its Wolbachia endosymbiont. These findings offer a foundation for rational drug design.
Subfields: Infectious Diseases, Insect Science, Plant Science
View Paper: https://www.semanticscholar.org/paper/adf13dd2f3203320b94fa6b7acc6d23eddca4158
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In Infectious Diseases
In Plant Science
- Bernard Henrissat
- Marc Robinson-Rechavi
- Matthew Berriman
- Feng Chen
- David S. Roos
- T. Tytgat
- Mark L. Blaxter
Citations in the corpus
- Genome sequence of the metazoan plant-parasitic nematode Meloidogyne incognita (2008, background): “1 online), as shown by the substantial differences between their genome sequences and that of the human parasite Brugia malayi”
- Helminth immunoregulation: The role of parasite secreted proteins in modulating host immunity (2009, background): “Available parasitic helminth genomes encode >10,000 genes [23], a figure supported by independent transcriptomic analyses [24,25].”
- Genomic-scale prioritization of drug targets: the TDR Targets database (2008, background): “Until recently, pathogenic worms were a striking exception, but the genome sequence of the filarial Brugia worm has recently been published 5 , and at least a dozen helminth genome projects are in progress.”