Genomic-scale prioritization of drug targets: the TDR Targets database
By Fernán Agüero, B. Al-Lazikani, M. Aslett, Matthew Berriman, F. Buckner, R. Campbell, Santiago J. Carmona, Ian M. Carruthers, A. Chan, Feng Chen and 18 more. Nature reviews. Drug discovery, 2008
310 citations recorded by the source corpus.
The increasing availability of genomic data for pathogens that cause tropical diseases has created new opportunities for drug discovery and development. However, if the potential of such data is to be fully exploited, the data must be effectively integrated and be easy to interrogate. Here, we discuss the development of the TDR Targets database (http://tdrtargets.org), which encompasses extensive genetic, biochemical and pharmacological data related to tropical disease pathogens, as well as computationally predicted druggability for potential targets and compound desirability information. By allowing the integration and weighting of this information, this database aims to facilitate the identification and prioritization of candidate drug targets for pathogens.
Subfields: Infectious Diseases, Molecular Biology, Pharmacology
View Paper: https://www.semanticscholar.org/paper/528b4fbfbcb2bf858b1745399fcccd3436885c42
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Citations in the corpus
- DEG 10, an update of the database of essential genes that includes both protein-coding genes and noncoding genomic elements (2013, background): “The accumulation of essential-gene information will be particular helpful in identifying bacterial drug targets (47) and in constructing the minimal genome in studies of synthetic biology (4).”
- Structure-based Systems Biology for Analyzing Off-target Binding (2011, background): “The selection of anti-infectious drug targets in pathogens is focused on those targets that are essential for the growth and survival of the organism, and which are frequently mapped from the orthologous genes in model organisms [31].”