IL-6 as a keystone cytokine in health and disease

By Christopher A. Hunter, Simon A. Jones. Nature Immunology, 2015

2,310 citations recorded by the source corpus.

Subfields: Immunology, Oncology, Pathology and Forensic Medicine

View Paper: https://www.semanticscholar.org/paper/add2d65f63128a6d756bc9c0d9b5d6fb1b554c6c

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Immunology

1. Shinwan Kany
2. T. Hirano
3. F. Powrie
4. Huiyuan Zhang
5. S. Watowich
6. B. Relja
7. Jan T Vollrath

In Oncology

1. Shinwan Kany
2. T. Hirano
3. B. Relja
4. Jan T Vollrath

In Pathology and Forensic Medicine

1. T. Hirano
2. F. Powrie

Citations in the corpus

• Cytokine release syndrome (2018, background): “Via trans-signaling IL-6 leads to characteristic symptoms of severe CRS, i.e. vascular leakage, and activation of the complement and coagulation cascade inducing disseminated intravascular coagulation (DIC) [57, 60].”
• Cytokine Networks in the Pathophysiology of Inflammatory Bowel Disease. (2019, background): “IL-6 however also promotes survival and cytokine secretion by Th1, Th2 or Th17 CD4 T cells (Hunter and Jones, 2015), which may in part reflect the general ability of IL-6 signalling in T cells to prevent apoptosis (Atreya et al.”
• Cytokines in Inflammatory Disease (2019, background): “Currently, similar to the C-reactive protein (CRP), IL-6 is used to “monitor” inflammation levels in patients with cancer, infection, or autoimmune diseases [33,34].”
• IL-6 in inflammation, autoimmunity and cancer (2020, background): “Other inhibitors against the IL-6–STAT3 signaling pathway are under development (19, 21, 24–26, 76, 374).”
• Structural insights into the assembly and activation of the IL‐27 signaling complex (2022, neutral): “GP130 binds a range of cytokines to elicit diverse cellular responses (Grotzinger et al , 1997; Hunter & Jones, 2015).”
• The cytokine storm in COVID-19: An overview of the involvement of the chemokine/chemokine-receptor system (2020, neutral): “The production of this cytokine is increased by IL-1β and tumor necrosis factor (TNF- α) [23].”
• STAT3 signaling in immunity (2016, background): “IL-21-induced STAT3 stimulates expression of the B cell maturation factor Blimp-1 and thereby drives IgG-producing plasma cell generation [191–194].”