A DNA replication mechanism for generating nonrecurrent rearrangements associated with genomic disorders.

By Jennifer A. Lee, C. Carvalho, J. R. Lupski. Cell, 2007

907 citations recorded by the source corpus.

Subfields: Genetics, Molecular Biology, Plant Science

View Paper: https://www.semanticscholar.org/paper/adcdc9dbfc38d10362e69a3d8d286b082edd7afa

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Genetics

1. M. Lieber
2. Feng Zhang
3. W. Gu
4. P. Hallast
5. G. Ira
6. P. Hastings
7. Dana Branzei
8. M. Foiani

In Molecular Biology

1. M. Lieber
2. Feng Zhang
3. W. Gu
4. Dana Branzei
5. J. R. Lupski
6. G. Ira
7. M. Foiani
8. P. Hallast

In Plant Science

1. M. Lieber
2. Feng Zhang
3. W. Gu
4. P. Hallast
5. G. Ira
6. P. Hastings
7. J. R. Lupski

Citations in the corpus

• The Mechanism of Double-Strand DNA Break Repair by the Nonhomologous DNA End Joining Pathway (2010, background): “Replication-based mechanisms are also likely to be very important for major genomic rearrangements (151, 152).”
• Patterns of somatic structural variation in human cancer genomes (2020, neutral): “3, 4) share important morphological features: (1) genomic configurations that can be phased to a single derivative chromosome; (2) low-level gains in copy number, especially duplications and triplications; (3) a high frequency of inverted rearrangements in addition to noninverted rearrangements; (4)”
• Maintaining genome stability at the replication fork (2010, background): “3 ), or with a strand from a distant RF that contains microhomology elements and is brought nearby by chromatin looping events, could lead to genome rearrangement”
• A Microhomology-Mediated Break-Induced Replication Model for the Origin of Human Copy Number Variation (2009, background): “[22] to explain the observations of nonrecurrent chromosomal changes seen in Pelizaeus-Merzbacher disease discussed”
• Human and chimpanzee Luteinizing hormone/ Chorionic Gonadotropin beta (LHB/CGB) gene clusters: diversity and divergence of young duplicated genes (2009, background): “…or pausing of the replication fork may be facilitated by genomic architectural elements (e.g. palindromic DNA, stem-loop structures, repeats, etc.) Lee et al. 2007 4 14 Mechanism Molecular basis Typical characteristics References SRS (Serial) slipped strand mispairing during replication –…”
• Genome Sequencing of Pediatric Medulloblastoma Links Catastrophic DNA Rearrangements with TP53 Mutations (2012, neutral): “NHEJ-mediated repair of shattered DNA fragments appears more likely to be involved in this context, as it is difficult to reconcile the model of MMBIR with the massive rearrangements (including complex double-minute chromosomes) we detected in association with chromothripsis.”
• Mechanisms of change in gene copy number (2009, background): “Most non-recurrent CNVs occur at sites of limited homology of 2–15 bp (microhomology) (for examples, see Ref”
• Mechanisms for human genomic rearrangements (2008, methodology): “Recently, the advent of array-based CGH [reviewed in [80,81]] has provided an unprecedented ability to observe the often complex details of genomic rearrangements, and has led to the proposal of the DNA replication-based FoSTeS model as the third major mechanism for human genomic rearrangements [82]”