In vivo aspects of protein folding and quality control

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Protein Misfolding, Amyloid Formation, and Human Disease: A Summary of Progress Over the Last Decade. (2017, background): “There is also evidence that the age-related accumulation of protein aggregates is both an effect and a cause of proteostasis network decline, driving a vicious cycle that ultimately leads to its collapse (81, 196).”
Assessing and enhancing foldability in designed proteins (2021, background): “We note, however, that the protein's ability to fold into the desired conformation also depends on other factors, such as the kinetic accessibility of the native state and the stability of folding intermediates.(46) These kinetic factors are not assessed by pSUFER, and it is unlikely that they can b”