Glimpses of a Tiny RNA World

By Gary Ruvkun. Science, 2001

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bantam encodes a developmentally regulated microRNA that controls cell proliferation and regulates the proapoptotic gene hid in Drosophila. (2003, background): “…reg-proteins that control cell proliferation and apoptosis have been identified, the means by which these ef- ulation of gene expression (reviewed in Ambros, 2001; Ruvkun, 2001). miRNAs are excised by the Dicer RNasefectors are linked to the patterning machinery remain poorly understood.”
High expression of precursor microRNA‐155/BIC RNA in children with Burkitt lymphoma (2004, background): “…and trigger either translation repression or direct RNA cleavage via RNA interference, depending on the degree of complementarity with the specific target mRNA (Ambros, 2001; Lagos-Quintana et al., 2001; Ruvkun, 2001; Lai, 2002; Pasquinelli, 2002; Ambros et al., 2003; Lagos-Quintana et al., 2003).”
Reprogramming of mouse and human cells to pluripotency using mature microRNAs. (2011, background): “MicroRNAs (miRNAs) are well-characterized regulators of development and differentiation (Lee et al., 1993; Ruvkun, 2001).”
A biochemical framework for RNA silencing in plants. (2003, background): “Animal miRNAs are only partially complementary to their target mRNAs; this partial complementarity has been proposed to cause miRNAs to repress translation of their targets, rather than direct target cleavage by the RNAi pathway (for review, see Ruvkun 2001; Hutva ´ gner and Zamore 2002).”