Biochemistry, cellular and molecular biology, and physiological roles of the iodothyronine selenodeiodinases.

By A. Bianco, Domenico Salvatore, B. Gereben, Marla J. Berry, P. Larsen. Endocrine reviews, 2002

1,824 citations recorded by the source corpus.

Subfields: Endocrinology, Diabetes and Metabolism, Molecular Biology, Nutrition and Dietetics

View Paper: https://www.semanticscholar.org/paper/ad1ffa125a7939a9d51af9e32b2c2acb5e3fa530

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Endocrinology, Diabetes and Metabolism

1. G. Brent
2. D. Cooper
3. B. Biondi

In Molecular Biology

1. G. Brent
2. D. Hatfield
3. Vadim N. Gladyshev
4. A. Bianco
5. Brian W Kim

In Nutrition and Dietetics

1. G. Brent
2. Vadim N. Gladyshev
3. D. Hatfield
4. M. Rayman

Citations in the corpus

• The clinical significance of subclinical thyroid dysfunction. (2008, background): “Furthermore, the biological activity of thyroid hormone, in terms of T3 availability, is regulated by type 1, 2, and 3 iodothyronine deiodinases (D1, D2, and D3) (45).”
• Thyroid status, disability and cognitive function, and survival in old age. (2004, background): “These low levels of triiodothyronine are thought to be the consequence of a decreased conversion of thyroxine into triiodothyronine by a lower capacity or a lower amount of 5 selenodeiodinase in peripheral tissues due to disease-related factors.(44,45) In our study, we found significant associations”
• The Molecular and Endocrine Basis of Flatfish Metamorphosis (2008, background): “The conversion of T 4 into the biologically active T 3 and subsequent inactivation of these THs occurs through the action of a family of selenocysteine protein enzymes known as deiodinases ( Bianco et al, 2002 ; Kohrle, 2000 ).”
• Deiodinases: implications of the local control of thyroid hormone action. (2006, neutral): “Thyroid hormone 3,5,3 ′ -triiodothyronine (T3) and its precursor thyroxine (T4) are iodinated compounds known to influence gene expression in virtually every vertebrate tissue.”
• Guidelines for the Treatment of Hypothyroidism: Prepared by the American Thyroid Association Task Force on Thyroid Hormone Replacement (2014, positive): “A third deiodinase, type 3 deiodinase (D3) participates in the clearance of both serum T4 and T3 (11).”
• From Selenium to Selenoproteins: Synthesis, Identity, and Their Role in Human Health (2007, neutral): “T3 levels are known to induce DIO1 expression at the transcriptional level (34), which”
• Selenoproteins: molecular pathways and physiological roles. (2014, background): “During normal development, DI2 expression reaches maximum levels in skeletal muscles just after birth and then decreases in the postnatal period.”
• Mechanisms of thyroid hormone action. (2012, positive): “The selective actions of thyroid hormone receptors are influenced by local ligand availability (1, 16); by transport of thyroid hormone into the cell by monocarboxylate transporter 8 (MCT8) or other related transporters (17); by the relative expression and distribution of the TR isoforms (13) and nu”