JNK signaling pathway is a key modulator in cell death mediated by reactive oxygen and nitrogen species.

By Han-Ming Shen, Zheng-Gang Liu. Free Radical Biology & Medicine, 2006

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Redox Regulation of Cell Survival (2008, positive): “In response to oxidative stress, JNK and p38 activation can induce both intrinsic and extrinsic pathways of apoptosis and necrosis (206, 280).”
Mechanisms of Cell Death in Oxidative Stress (2007, neutral): “With respect to p38 MAPK, cell culture experiments indicate that activation of p38 MAPK by UVA/B is generally”
Microbial degradation of imidacloprid and toxicological analysis of its biodegradation metabolites in silkworm (Bombyx mori) (2013, background): “ROS and oxidative stress have been shown to be triggers of apoptosis [36].”
Cisplatin Induces a Mitochondrial-ROS Response That Contributes to Cytotoxicity Depending on Mitochondrial Redox Status and Bioenergetic Functions (2013, background): “have been shown to be activated by ROS and induce cell death [55–57].”