Angiopoietin-1 regulates endothelial cell survival through the phosphatidylinositol 3'-Kinase/Akt signal transduction pathway.

By Injune Kim, H. Kim, J. So, Joo H. Kim, H. Kwak, G. Koh. Circulation Research, 2000

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Ablation in mice of the mTORC components raptor, rictor, or mLST8 reveals that mTORC2 is required for signaling to Akt-FOXO and PKCalpha, but not S6K1. (2006, background): “Tie2, when activated by its ligand, Angiopoietin-1, signals through PI3K to regulate vascular development (Kim et al., 2000; Papapetropoulos et al., 2000).”
Control of vascular morphogenesis and homeostasis through the angiopoietin–Tie system (2009, background): “ANG1-mediated TIE2 activation in non-resting ECs induces several aspects of the angiogenic cascade, including three-dimensional capillary organization, proliferation and increased expression of basement-membrane-degrading protease”