Epigenetic Reprogramming in Mammalian Development

By Wolf Reik, W. Dean, Jörn Walter. Science, 2001

3,093 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/ac4a218d182a140336f89a7021544190cbf9d6cb

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Citations in the corpus

Epigenetic codes for heterochromatin formation and silencing: rounding up the usual suspects. (2002, background): “The best example is the erasure and resetting dim-5 mutation causes more phenotypic defects than of cytosine methylation in early mammalian develop- the dim-2 cytosine methyltransferase mutation, sugment (Reik et al., 2001).”
Prenatal tobacco smoke exposure affects global and gene-specific DNA methylation. (2009, background): “In mammals, there are at least two developmental periods, in germ cells and in preimplantation embryos, in which methylation patterns are reprogrammed genome wide, generating cells with a broad developmental potential (6).”
Aberrant epigenetic landscape in cancer: how cellular identity goes awry. (2010, background): “…undergo genome-wide alterations that occur immediately after fertilization and during early preimplantation development (Mayer et al., 2000; Reik et al., 2001) and that enrichment of individual histone modifications (such as H3K9me, H3K4me and H3K27me3) also varies in a specific manner at…”
The Dynamics of Genome-wide DNA Methylation Reprogramming in Mouse Primordial Germ Cells (2012, background): “Epigenetic information in the mammalian genome is relatively stable in differentiated cells of the soma but is reprogrammed on a genome-wide scale in primordial germ cells (PGCs) and early embryos (Reik et al., 2001; Surani et al., 2007; Sasaki and Matsui, 2008; Smith et al., 2012).”
A unique regulatory phase of DNA methylation in the early mammalian embryo (2012, methodology): “The classical model is drawn from observations made using either global measurements, such as immunohistochemistry, or from limited analysis at individual loci using bisulfite sequencing 11,12,15–22 .”
Epigenetic reprogramming in mouse primordial germ cells. (2002, neutral): “It is therefore important to discover the role of demethylation as well as the nature of this key modifier, which is of wider interest in the context of genomic plasticity, pluripotency of stem cells, and cloning (Reik et al., 2001; Surani, 2001).”
5-Hydroxymethylcytosine in the mammalian zygote is linked with epigenetic reprogramming. (2011, background): “The reprogramming of DNA methylation has a direct influence on genomic imprints, the regulation of pluripotency and stem cell networks, the erasure of epimutations and the transcriptional control of transposon”
Tet1 and Tet2 regulate 5-hydroxymethylcytosine production and cell lineage specification in mouse embryonic stem cells (2011, background): “…blastocyst implantation, to a greater extent in the inner cell mass (ICM), which remains pluripotent and gives rise to all cell types of the embryo proper, than in the outer trophectoderm (TE) layer, which is restricted to an extraembryonic fate and gives rise to the placenta (Reik et al., 2001).”
Persistent epigenetic differences associated with prenatal exposure to famine in humans (2008, background): “Early embryonic development is of special interest in this respect, because this is a crucial period for establishing and maintaining epigenetic marks (5).”
Tissue Distribution of 5-Hydroxymethylcytosine and Search for Active Demethylation Intermediates (2010, background): “Whereas it is well established that mC is a crucial epigenetic marker [3], the function of the sixth base hmC is currently unknown, but it is speculated that it is involved in epigenetic regulation events or in active demethylation processes [4,5,6,7,8].”