The inflammasome recognizes cytosolic microbial and host DNA and triggers an innate immune response
By D. Muruve, Virginie Petrilli, Anne-Kathrin Zaiss, Lindsay R. White, Sharon A. Clark, P. Ross, R. Parks, J. Tschopp. Nature, 2008
1,017 citations recorded by the source corpus.
Subfields: Immunology, Molecular Biology
View Paper: https://www.semanticscholar.org/paper/ab719574c992938eee805795a74d7e0914360a7f
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In Immunology
In Molecular Biology
- J. Tschopp
- Kate Schroder
- Guido Kroemer
- E. Latz
- Shizuo Akira
- L. Galluzzi
- Fabio Martinon
- Katherine A. Fitzgerald
Citations in the corpus
- Plasmacytoid dendritic cells: sensing nucleic acids in viral infection and autoimmune diseases (2008, background): “Second, in macrophages, cytoplasmic DNA has been shown to trigger pro-inflammatory responses through components of the inflammasome , a process that is independent of TLRs and IRF”
- The inflammasomes. (2010, positive): “Ligand requirements for AIM2 are quite permissive, as cytosolic dsDNA from virus, bacteria, or the host itself can activate the AIM2 inflammasome (Hornung et al., 2009; Muruve et al., 2008).”
- The Airway Epithelium: Soldier in the Fight against Respiratory Viruses (2011, background): “While NOD1 and NOD2, the first NLRs identified, are involved mainly in the recognition of bacterial peptidoglycans, NLRP3 seems to be important for the immune response to respiratory viruses (5, 118, 192, 280).”
- Cytokines in Radiobiological Responses: A Review (2012, neutral): “These can also be activated by microbial and host DNA independent of TLRs (81), where DNA binding proteins seem to play a major role.”
- The Inflammasome NLRs in Immunity, Inflammation, and Associated Diseases (2011, background): “A role for NLRP3 in response to adenovirus, herpes virus, and vaccinia virus was suggested by in vitro experiments (65, 66).”
- An orthogonal proteomic-genomic screen identifies AIM2 as a cytoplasmic DNA sensor for the inflammasome (2009, background): “, thereby initiating a signal-transduction cascade that leads to the proteolytic maturation of interleukin-1β (IL-1β”
- NLRP3 inflammasome: From a danger signal sensor to a regulatory node of oxidative stress and inflammatory diseases (2015, background): “…infantile neurological cutaneous articular syn ; DD, death domains; FCAS, familial cold autoi yloid-containing amylin—islet amyloid polyp e-1; LDL, low density lipoprotein; LDLR, LDL re Wells syndrome; NBD, nucleotide-binding do eficient mice3; NLRs, receptors; NOMID, neon ; oxLDL,…”