Multiple molecular mechanisms for multidrug resistance transporters

By C. Higgins. Nature, 2007

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Multidrug Resistance in Bacteria (2009, background): “Structures and possible mechanisms of these transporters have been reviewed recently (49)”
Efflux-Mediated Drug Resistance in Bacteria: an Update (2009, background): “Although antibacterial resistance occurs by numerous mechanisms, including enzymatic inactivation or modification of drugs, drug target alteration or protection, and lack of pro-drug activation, that due to the increased active efflux of the drugs is a major concern especially because a single speci”
Inward-facing conformation of a multidrug resistance MATE family transporter (2019, positive): “According to the basic principles of the alternating access model (17, 18), MATE transporters sequentially expose their substrate-binding cavity to either side of the membrane during a transport cycle by internal or external barrier formation.”
Chapter 11 - Reconstitution of membrane proteins in phospholipid bilayer nanodiscs. (2009, background): “P-gp is a member of the ATP-binding cassette (ABC) transporter family which has been implicated in the phenomenon of multidrug resistance in tumor cells (Higgins, 2007), as well as the absorption and disposition of many pharmaceutical compounds (Zhou, 2008), yet there is still a great deal about the”