The metabolic syndrome: time for a critical appraisal

By R. Kahn, John B. Buse, E. Ferrannini, M. Stern. Diabetologia, 2005

2,364 citations recorded by the source corpus.

Subfields: Endocrinology, Diabetes and Metabolism, Epidemiology

View Paper: https://www.semanticscholar.org/paper/aa890e7a14fb6565498c347ff94cc84c469caa0d

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Endocrinology, Diabetes and Metabolism

1. R. Eckel
2. Ralph B. D’Agostino
3. Lisa Sullivan
4. R. Juster
5. E. Gale
6. R. Norman
7. Sonia J. Lupien
8. D. Nathan

In Epidemiology

1. R. Eckel
2. R. Norman
3. James B. Meigs
4. Peter W. F. Wilson
5. Bruce S. McEwen
6. S. Fried
7. Ralph B. D’Agostino

Citations in the corpus

• Regulatory role for the arginine-nitric oxide pathway in metabolism of energy substrates. (2006, background): “Since its initial description by Reaven [141], there has been considerable debate about the precise definition of the metabolic syndrome or Syndrome X [142].”
• Positions statement: criteria for defining polycystic ovary syndrome as a predominantly hyperandrogenic syndrome: an Androgen Excess Society guideline. (2006, background): “taken when defining the limits of the metabolic syndrome (22).”
• Body mass index, metabolic syndrome, and risk of type 2 diabetes or cardiovascular disease. (2006, background): “Whether IR underlies the risk factor clustering embodied in ATP3 MetS is the subject of debate (38).”
• A comprehensive definition for metabolic syndrome (2009, background): “This clustering of some risk factors and their shared responsiveness to lifestyle modifications suggests that they are not independent of one another and that they share underlying causes, mechanisms and features (Grundy et al., 2005; Kahn et al., 2005).”
• The metabolic syndrome: useful concept or clinical tool? Report of a WHO Expert Consultation (2010, background): “Critics of the concept have pointed out that, despite an exponential increase in the number of research papers on the subject, no single unifying pathophysiological mechanism has been agreed, and the equivalence of the risk factors and their cut-off points across different populations has not been e”
• Allostatic load biomarkers of chronic stress and impact on health and cognition. (2010, background): “…Bogardus, 2009; Stumvoll et al., 2003, 2004), and incorporation of biomarkers not currently included in metabolic syndrome nomenclature (i.e., leptin, cortisol; (Chrousos, 2000; Kahn et al., 2005; Maggio et al., 2006, 2007; Rosmond, 2005)) will be essential for research and clinical practice alike.”