Interplay of hippocampus and prefrontal cortex in memory

By Alison R. Preston, Howard Eichenbaum. 2013

1,312 citations recorded by the source corpus.

Recent studies on the hippocampus and the prefrontal cortex have considerably advanced our understanding of the distinct roles of these brain areas in the encoding and retrieval of memories, and of how they interact in the prolonged process by which new memories are consolidated into our permanent storehouse of knowledge. These studies have led to a new model of how the hippocampus forms and replays memories and how the prefrontal cortex engages representations of the meaningful contexts in which related memories occur, as well as how these areas interact during memory retrieval. Furthermore, they have provided new insights into how interactions between the hippocampus and prefrontal cortex support the assimilation of new memories into pre-existing networks of knowledge, called schemas, and how schemas are modified in this process as the foundation of memory consolidation.

Subfields: Cellular and Molecular Neuroscience, Cognitive Neuroscience

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Citations in the corpus

The hippocampus and related neocortical structures in memory transformation. (2018, background): “Investigation into the application of these constructs in animal research is just beginning [35,36], and we will note its development as we proceed through the paper.”
The successor representation in human reinforcement learning (2016, methodology): “Ventromedial PFC is well connected to the hippocampus 47 and is thought to mediate sampling information from episodic memory with the goal of decision-making 55 and consolidation 56,57 , as well as the comparison and integration of value, abstract state-based inference 58 , and latent causes 59 .”
Bidirectional Interaction of Hippocampal Ripples and Cortical Slow Waves Leads to Coordinated Spiking Activity During NREM Sleep. (2020, background): “The hippocampo-cortical dialogue is critical for consolidation of memories (Preston and Eichenbaum 2013).”
Episodic Memory and Beyond: The Hippocampus and Neocortex in Transformation (2016, neutral): “…2015), aHPC activity is associated with the general locations where events occurred or coarse map-like representations of those locations, whereas activity in the pHPC is associated with local details or finer-grained maps (for comparable results in rodents see review in Preston & Eichenbaum 2013).”
Self-Net: Lifelong Learning via Continual Self-Modeling (2018, background): “As noted in [15], during learning the brain first forms an initial neural representation in cortical regions; the hippocampus then consolidates this representation into a form that is optimized for storage and retrieval.”
A Scalable Approach to Multi-Context Continual Learning via Lifelong Skill Encoding (2018, background): “As noted in [6], during learning the brain first forms an initial neural representation in cortical regions; the hippocampus then consolidates this representation into a form that is optimized for storage and retrieval.”
The Effects of Acute Exercise on Mood, Cognition, Neurophysiology, and Neurochemical Pathways: A Review (2016, background): “As the prefrontal cortex is a recipient of this sequential activity from the hippocampus [77, 78], prefrontal cortical neurons exhibit similar predictive or preparatory behavior during running [79], which is of particular interest as prefrontal cortex function clearly benefits from acute exercise (s”
Effects of Prior Knowledge on Memory: Implications for Education. (2016, methodology): “…by making use of prior knowledge, the medial part of the PFC seems to be involved in detecting fit or congruency between new information and prior knowledge during encoding and retrieval (Hebscher & Gilboa, 2016; Moscovitch & Winocur, 2002; Preston & Eichenbaum, 2013; van Kesteren et al., 2012).”
Offline replay supports planning in human reinforcement learning (2018, background): “, 2013), and the ventromedial prefrontal cortex has been established as a region involved in memory retrieval of relevant information (Preston and Eichenbaum, 2013; Gläscher et al., 2009), value representation (Fellows and Farah, 2007), and decision making Figure 4 continued”
An intracranial dissection of human escape circuits (2024, unknown): “The synchrony between the PFC and the HPC has been consistently associated with various cognitive functions, including memory, learning, and defensive behavior 78,83,85,86 .”