The frailty of adaptive hypotheses for the origins of organismal complexity

By Michael Lynch. Proceedings of the National Academy of Sciences of the United States of America, 2007

754 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/aa57bb94ef4c5e88233de0564f2974bcdd76f715

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Citations in the corpus

Revising the evolutionary computation abstraction: minimal criteria novelty search (2010, background): “However, a consensus in biology is building that the pressure to maximize fitness may not be responsible for complexity growth in natural evolution [12, 18, 21].”
The Evolution and Emergence of RNA Viruses (2009, background): “In particular, Mike Lynch (Indiana University) has argued in a series of elegant and provocative papers that large-scale features of genome organization in eukaryotes and prokaryotes, such as the numbers of duplicated genes, mobile elements, and introns, are the result of random (or, in his terminol”
Copying and Evolution of Neuronal Topology (2008, background): “Although not without its critics [30], increasingly there is an understanding that natural selection is capable of acting self-”
Pseudomonas aeruginosa population structure revisited under environmental focus (2010, background): “…and driven by the population genetic forces of mutation, recombination, natural selection and genetic drift (Hartl & and Clark, 2007; Lynch, 2007a; Lynch, 2007b) Natural selection is the process by which an organism that displays favorable characteristics has a higher probability to leave…”
Abandoning Objectives: Evolution Through the Search for Novelty Alone (2011, background): “However, as Lynch (2007b) and Miconi (2007) suggest, it is often when the reigns of selection pressure are lifted that evolution innovates most proliﬁcally.”
What is Systems Biology? (2010, background): “The fact that the evolution of complex systems, the emergence of high-level features like robustness and modularity, is largely driven by non-adaptive processes (Lynch, 2007a,b) makes the decision even more challenging.”
Epistasis—the essential role of gene interactions in the structure and evolution of genetic systems (2008, background): “This is more because of the overall structural dependence induced by historical contingency than because it is a result of some intricately pieced-together machin”
The strain concept in phytoplankton ecology (2009, background): “Aside from valid criticisms of this adaptationist paradigm (Gould and Lewontin, 1979; Brand, 1984; Lynch, 2007), these discussions all too often ignore adaptation to the culture conditions inwhich the strains are subsequently maintained.”
Phytozome: a comparative platform for green plant genomics (2011, background): “As orthologs are assumed to more likely share a common biological function, while paralogs are subject to both neo-and subfunctionalization (41,42), the high confidence identification of orthologs allows for the transfer of functional information from well-studied, tractable model systems (e.g.,…”
Exploiting Open-Endedness to Solve Problems Through the Search for Novelty (2008, background): “Researchers like Miconi [19] in artificial life, and Lynch [14] [15] in biology are arguing that natural selection does not always explain increases in evolutionary complexity.”
Transcription factor binding in human cells occurs in dense clusters formed around cohesin anchor sites. (2013, neutral): “…role of particular TF combinations in cell fate determination and development (Levine, 2010; Takahashi and Yamanaka, 2006), most combinations of TFs observed are not the result of an adaptive process (see also Lynch, 2007), but represents binding of TFs to weak sites located in accessible DNA.”
Turning a hobby into a job: How duplicated genes find new functions (2008, background): “However, not all gene duplications involve functional innovation: in the years since Ohno's monograph we have realized that many (or even most) gene duplicates do not confer novel functions and are probably preserved in the genome by passive mechanisms such as subfunctionalization”
Robustness and Evolvability (2010, background): “Evolution of Evolvability Some authors have argued that it is impossible for natural selection to favor evolvability [93,94].”