Transcription factor binding in human cells occurs in dense clusters formed around cohesin anchor sites.
By Jian Yan, M. Enge, Thomas Whitington, Kashyap Dave, Jianping Liu, Inderpreet Sur, Bernhard Schmierer, A. Jolma, Teemu Kivioja, Minna Taipale and 1 more. 2013
380 citations recorded by the source corpus.
Subfields: Molecular Biology, Plant Science
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The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.
In Molecular Biology
- Rebecca M. Truty
- Samuel A. Lambert
- Katherine S. Pollard
- Sean Whalen
- Mihai Albu
- Joseph R. Ecker
- Xiaoting Chen
- Gunnar Rätsch
In Plant Science
Citations in the corpus
- Determination and Inference of Eukaryotic Transcription Factor Sequence Specificity (2014, positive): “The most prevalent method for in vivo analysis is currently chromatin immunoprecipitation sequencing (ChIP-seq) (Barski and Zhao, 2009; Park, 2009), but ChIP does not inherently measure relative preference of a TF to individual sequences and may not identify correct TF motifs due tocomplicating fact”
- The mechanisms behind the therapeutic activity of BET bromodomain inhibition (2014, background): “…studies describe a similar phenomenon in which a specific subset of regulatory DNA elements exhibits high levels of occupancy for TFs, histone modifications, and/or coregulators (e.g., stretch enhancers and HOT regions) (modENCODE Consortium et al., 2010; Parker et al., 2013; Yan et al., 2013).”
- Enhancer-promoter interactions are encoded by complex genomic signatures on looping chromatin (2016, methodology): “Alternate promoter and enhancer definitions Before transitioning to annotation-based enhancers, we defined candidate enhancers as transcription factor binding sites (TFBS) identified by CENTIPEDE [6], lifted these over from the hg18 to hg19 assembly, and clustered them [7] using the DBSCAN algorithm”