Autoimmune-associated lymphoid tyrosine phosphatase is a gain-of-function variant

By T. Vang, M. Congia, M. D. Macis, L. Musumeci, V. Orrù, P. Zavattari, K. Nika, L. Tautz, K. Taskén, F. Cucca and 2 more. Nature Genetics, 2005

759 citations recorded by the source corpus.

Subfields: Genetics, Immunology, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/aa4ae54da5d4e031cb7fe7d44493f58af87afdac

How researchers see this paper

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In Genetics

1. Ta-Chiang Liu
2. Shimon Sakaguchi
3. T. Stappenbeck

In Immunology

1. Shimon Sakaguchi
2. T. Nomura
3. M. Ono
4. E. Shevach
5. Alexander Y. Rudensky
6. W. Zou

In Molecular Biology

1. Ta-Chiang Liu
2. T. Stappenbeck

Citations in the corpus

• GENETICS AND PATHOGENESIS OF INFLAMMATORY BOWEL DISEASE (2016, background): “PTPN22, a protein kinase phosphatase expressed mainly in hematopoietic cells, is associated with other immune diseases, including rheumatoid arthritis, systemic lupus erythematosus, type 1 diabetes, multiple sclerosis, and Grave’s disease (53).”
• Foxp3+CD25+CD4+ natural regulatory T cells in dominant self‐tolerance and autoimmune disease (2006, background): “This alteration leads to an increase in tyrosine dephosphorylation of TCR proximal signaling molecules (such as Lck, TCR z-chain, ZAP-70, and LAT), hence a reduction in TCR signaling and less IL-2 production by T cells (150).”