GENETICS AND PATHOGENESIS OF INFLAMMATORY BOWEL DISEASE

By Ta-Chiang Liu, T. Stappenbeck. Annual Review of Pathology, 2016

1,128 citations recorded by the source corpus.

We are currently in an exciting time where our understanding of genetic underpinnings of inflammatory bowel disease (IBD) has undergone a revolution, based in large part by novel genotyping and sequencing technologies. With >160 susceptible loci identified for IBD, the goals now are to understand at a fundamental level, the function of these susceptibility alleles. Clinical relevance of how these susceptible genes shape the development of IBD is also a high priority. The main challenge is to understand how the environment and microbiome play a role in triggering disease in genetically susceptible individual, as the interactions may be complex. To advance the field, novel in vitro and mouse models that are designed to interrogate complex genetics and be able to functionally test hypotheses are needed. Ultimately, the goal of genetics studies will be to translate genetics to the patients with IBD and improve their care.

Subfields: Genetics, Infectious Diseases, Surgery

View Paper: https://www.semanticscholar.org/paper/4138ec45eb14b5ce9b4aa1ba56458627cc548d9f

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Citations in the corpus

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How informative is the mouse for human gut microbiota research? (2015, background): “Swine gut microbiota has been investigated in several studies, especially involving antibiotic interventions (Kim et al., 2012), which are of industrial relevance.”
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