An epidemic, toxin gene-variant strain of Clostridium difficile.
By L. McDonald, G. Killgore, Angela D. Thompson, R. Owens, Sophia V. Kazakova, S. Sambol, Stewart C Johnson, D. Gerding. New England Journal of Medicine, 2005
2,080 citations recorded by the source corpus.
Subfields: Infectious Diseases, Molecular Biology
View Paper: https://www.semanticscholar.org/paper/aa1ecb56b61ba04177a5279d04a9d6c692276608
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Citations in the corpus
- The multidrug-resistant human pathogen Clostridium difficile has a highly mobile, mosaic genome (2006, background): “This has been illustrated by the recent emergence of the hypervirulent NAP1/027 strain in North American hospitals, resulting in significantly increased mortality rate”
- Trends in U.S. Burden of Clostridioides difficile Infection and Outcomes. (2020, neutral): “Open Forum Infect Dis 2017; 4(4): ofx171.”
- Antibiotics and Bacterial Resistance in the 21st Century (2014, background): “The new first in class antibiotics introduced for human use are the streptogramin combination quinupristin (69) / dalfopristin (70) in 1999, the oxazolidinone linezolid (74) in 2000, the lipopeptide daptomycin (79) in 2003, the pleuromutilin retapmulin (81) in 2007, the macrolactone fidaxomicin (83)”
- A Guide to Utilization of the Microbiology Laboratory for Diagnosis of Infectious Diseases: 2013 Recommendations by the Infectious Diseases Society of America (IDSA) and the American Society for Microbiology (ASM)a (2013, background): “It produces both toxin A and toxin B [112].”
- Clinical Practice Guidelines for Clostridium difficile Infection in Adults and Children: 2017 Update by the Infectious Diseases Society of America (IDSA) and Society for Healthcare Epidemiology of America (SHEA). (2018, positive): “The recent isolates of the 027 strain are more highly resistant to fluoroquinolones compared to historic strains of the same type [48].”
- Clostridium difficile--associated disease in a setting of endemicity: identification of novel risk factors. (2007, background): “ing [8, 9], but newly identified risk factors for these”
- Toxin B is essential for virulence of Clostridium difficile (2009, methodology): “DNA was purified from cultures grown in the absence (2) or presence (1) of thiamphenicol selection.”