Spectrum of gluten-related disorders: consensus on new nomenclature and classification
By A. Sapone, J. Bai, C. Ciacci, J. Dolinsek, P. Green, M. Hadjivassiliou, K. Kaukinen, K. Rostami, D. Sanders, M. Schumann and 5 more. BMC Medicine, 2012
1,135 citations recorded by the source corpus.
A decade ago celiac disease was considered extremely rare outside Europe and, therefore, was almost completely ignored by health care professionals. In only 10 years, key milestones have moved celiac disease from obscurity into the popular spotlight worldwide. Now we are observing another interesting phenomenon that is generating great confusion among health care professionals. The number of individuals embracing a gluten-free diet (GFD) appears much higher than the projected number of celiac disease patients, fueling a global market of gluten-free products approaching $2.5 billion (US) in global sales in 2010. This trend is supported by the notion that, along with celiac disease, other conditions related to the ingestion of gluten have emerged as health care concerns. This review will summarize our current knowledge about the three main forms of gluten reactions: allergic (wheat allergy), autoimmune (celiac disease, dermatitis herpetiformis and gluten ataxia) and possibly immune-mediated (gluten sensitivity), and also outline pathogenic, clinical and epidemiological differences and propose new nomenclature and classifications.
Subfields: Epidemiology, Gastroenterology, Surgery
View Paper: https://www.semanticscholar.org/paper/504cced55b812a1b9e9b5d5714046860ff3d699f
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Citations in the corpus
- Human Intestinal Barrier Function in Health and Disease (2016, background): “This condition is classified as non-celiac gluten sensitivity.(124) It is not completely clear if gluten or other components in wheat are responsible for the symptoms,(125)”
- No effects of gluten in patients with self-reported non-celiac gluten sensitivity after dietary reduction of fermentable, poorly absorbed, short-chain carbohydrates. (2013, background): “The clinical entity of non-celiac gluten sensitivity (NCGS) has been defined as those without celiac disease but whose gastrointestinal symptoms improve on a glutenfree diet (GFD).(3,4) Since its original description in 1980,(5) reports of NCGS have not taken into account the presence of other compo”
- Wheat seed storage proteins: Advances in molecular genetics, diversity and breeding applications (2014, background): “Sapone et al. (2012) summarized the current knowledge about the 661 main forms of gluten reactions which may be allergic and autoimmune (coeliac disease, 662 dermatitis herpetiformis, and gluten ataxia).”