How cells handle cholesterol.

By K. Simons, Elina Ikonen. Science, 2000

1,242 citations recorded by the source corpus.

Subfields: Cell Biology, Molecular Biology, Surgery

View Paper: https://www.semanticscholar.org/paper/a99f36228ed59196c6270bc9829026fb126b6de7

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Citations in the corpus

Akt maintains cell size and survival by increasing mTOR-dependent nutrient uptake. (2002, background): “Cholesterol is an important component of cellular membranes and its incorporation impacts membrane fluidity as well as cell signaling through lipid rafts (Simons and Ikonen, 2000).”
LXR signaling couples sterol metabolism to proliferation in the acquired immune response (2008, background): “However, intracellular cholesterol trafficking is complex, and intracellular pools are not necessarily in equilibrium with the plasma membrane (Chang et al., 2006; Simons and Ikonen, 2000).”
Molecular Pathogenesis of Shigella spp.: Controlling Host Cell Signaling, Invasion, and Death by Type III Secretion (2008, background): “Cholesterol is a ubiquitous component of eukaryotic membranes and strongly influences their biophysical properties (283, 285).”
Melittin: a Membrane-active Peptide with Diverse Functions (2007, background): “role in membrane organization, dynamics, function and sorting (Yeagle 1985; Liscum and Underwood 1995; Simons and Ikonen 2000; Pucadyil and Chattopadhyay 2006).”
The Pharmacology of Sigma-1 Receptors (2009, background): “Lipid rafts are ganglioside-, sphingomyelin-, and cholesterol-enriched semi-gel lipid microdomains proposed to serve as signaling platforms for ion channels, receptors, and kinases (Simons & Ikonen, 2000).”
Caveolae: From Cell Biology to Animal Physiology (2002, background): “However, as will be discussed below, the answer might lie in the fact that some of the proposed functions for caveolae would suit certain cell types better than others.”
Advances in Planar Lipid Bilayers and Liposomes (2011, methodology): “23, the phase diagram of the phytantriol/water system, established by Barauskas and Landh [43].”
Membrane Lipid Composition: Effect on Membrane and Organelle Structure, Function and Compartmentalization and Therapeutic Avenues (2019, background): “Control of the carrying of cholesterol from the PM to the ER is governed by the arrangement of cholesterol in PM, which in turn is crucially restrained by the connection of cholesterol with SM [118] (reviewed in [116]).”
Studies on anticancer activities of antimicrobial peptides. (2008, background): “Leuschner and Hansel [67] have suggested that cholesterol, which is a major component of eukaryotic cell membranes [68], may protect eukaryotic cells from the cytolytic effect of antimicrobial peptides by altering membrane fluidity and thereby interfering with the membrane insertion of lytic peptide”
Human Immunodeficiency Virus Type 1 Assembly and Lipid Rafts: Pr55gag Associates with Membrane Domains That Are Largely Resistant to Brij98 but Sensitive to Triton X-100 (2003, background): “However, since cholesterol depletion affects many different cellular processes (28, 29, 44, 45), it could bring about reduction in HIV-1 particle production entirely through indirect effects as well.”
The human ATP-binding cassette (ABC) transporter superfamily. (2001, neutral): “Hydrogen bonding further strengthens the lateral association between the sterol ring and the ceramide backbone of SM moieties (58).”
Structure of N-terminal Domain of NPC1 Reveals Distinct Subdomains for Binding and Transfer of Cholesterol (2009, background): “The liberated cholesterol must then exit the lysosomal compartment in order to reach the plasma membrane and the endoplasmic reticulum (ER) where it performs structural and regulatory roles, respectively (Demel and De Kruyff, 1976; Simons and Ikonen, 2000; Goldstein et al., 2006).”