Human Mucosal Associated Invariant T Cells Detect Bacterially Infected Cells

By Marielle C. Gold, S. Cerri, S. Smyk-Pearson, M. Cansler, T. Vogt, J. Delepine, Ervina Winata, Gwendolyn M. Swarbrick, Wei-Jen Chua, Y. Y. Yu and 8 more. PLoS Biology, 2010

663 citations recorded by the source corpus.

A first indication of the biological role of mucosal associated invariant T (MAIT) cells reveals that this discrete T cell subset is broadly reactive to bacterial infection. In particular MAIT cells recognize Mycobacterium tuberculosis-infected lung airway epithelial cells via the most evolutionarily conserved major histocompatibility molecule.

Subfields: Epidemiology, Immunology

View Paper: https://www.semanticscholar.org/paper/e4836f7df4def7e0413ab805c034ffacab1e42a9

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In Immunology

1. D. Godfrey

Citations in the corpus

• IL‐12 and IL‐7 synergize to control mucosal‐associated invariant T‐cell cytotoxic responses to bacterial infection (2017, background): “104 Upon activation, MAIT cells rapidly express effector cytokines such as TNFα, IFNγ and IL105 17[24][25] and are also able to inhibit intracellular bacterial growth within infected 106 macrophages [26].”
• MR1 presents microbial vitamin B metabolites to MAIT cells (2012, methodology): “Compounds RL-6,7-diMe (1), RL-6-Me-7-OH (2) and a 2-electron reduced form of RL-6-CH2OH, namely rRL-6-CH2OH (3) were synthesized by modifications (Supplementary Fig.”