The molecular basis of vernalization: the central role of FLOWERING LOCUS C (FLC).

By C. Sheldon, D. Rouse, E. Finnegan, W. Peacock, E. Dennis. Proceedings of the National Academy of Sciences of the United States of America, 2000

700 citations recorded by the source corpus.

Subfields: Molecular Biology, Plant Science

View Paper: https://www.semanticscholar.org/paper/a946dae3c4c37557bc0f5f128d55cc34e3e8e283

How researchers see this paper

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In Molecular Biology

1. G. Coupland
2. M. Hanke
3. S. Tonsor
4. F. Fornara
5. F. Turck
6. M. Koornneef
7. C. Alonso‐Blanco
8. I. Bäurle

In Plant Science

1. G. Coupland
2. M. Hanke
3. S. Tonsor
4. F. Fornara
5. F. Turck
6. I. Bäurle
7. M. Koornneef
8. C. Alonso‐Blanco

Citations in the corpus

• The AGAMOUS-LIKE 20 MADS domain protein integrates floral inductive pathways in Arabidopsis. (2000, background): “Late-flowering ecotypes have dominant alleles of FRI and FLC that act synergistically to suppress flowering, whereas early-flowering ecotypes have a recessive allele of FRI and/or weak allele of FLC (Koornneef et al. 1994; Lee et al. 1994b; Sanda and Amasino 1995; Sheldon et al. 2000).”
• No Flower no Fruit - Genetic Potentials to Trigger Flowering in Fruit Trees (2007, background): “On the other hand, FLC is up-regulated by a set of genes, e.g. FRIGIDA (FRI) and VERNALIZATION INDEPENDENCE (VIP) (Michaels and Amasino 1999; Sheldon et al. 2000; Zhang and van Nocker 2002; Zhang et al. 2003).”
• The transcription factor FLC confers a flowering response to vernalization by repressing meristem competence and systemic signaling in Arabidopsis. (2006, background): “In response to vernalization, the abundance of FLC mRNA and protein is reduced (Michaels and Amasino 1999; Sheldon et al. 1999, 2000 ), and therefore vernalization promotes flowering by reducing FLC expression.”
• Gene function beyond the single trait: natural variation, gene effects, and evolutionary ecology in Arabidopsis thaliana (2005, background): “2000) and FLOWERING LOCUS C ( FLC ) (Sheldon et al .”
• Common mechanisms regulate flowering and dormancy (2009, background): “These genes act to repress FLC expression in response to increased temperatures [66].”
• Construct design for efficient, effective and high-throughput gene silencing in plants. (2001, methodology): “To measure the effect of silencing FLC1, 20±30 seeds from each transgenic C24 Arabidopsis line, the transposon mutant ̄c13 (Sheldon et al., 2000), and a control GUS line, were germinated and grown on kanamycin plates as described by Sheldon et al.”
• Naturally occurring genetic variation in Arabidopsis thaliana. (2004, background): “When the functional allelic variation results in gene expression differences, as found for several natural alleles of the FRI andFLC loci (58, 107, 148), this may give a clear indication of which is the candidate gene.”
• Control of flowering time: interacting pathways as a basis for diversity. (2002, background): “Therefore, FLC encodes a repressor of flowering, and highlevel expression of FLC correlates with the vernalization requirement of winter annual varieties (Michaels and Amasino, 1999b; Sheldon et al., 1999, 2000).”
• Potent Induction of Arabidopsis thaliana Flowering by Elevated Growth Temperature (2006, unknown): “Together with its upstream regulator FRI, FLC plays an important role in natural variation of Arabidopsis thaliana flowering [7– 9,11,12,18–21].”
• Reconsidering plant memory: Intersections between stress recovery, RNA turnover, and epigenetics (2016, background): “Significantly, investigations of the FLC loci have demonstrated that memory is mitotically stable (64); memory is quantitative, with the degree of repression of FLC reflecting the length of the cold exposure (65); yet, the epigenetic state of FLC is cell-specific and likely digital, that is, ON/OFF ”
• Multiple Pathways in the Decision to Flower: Enabling, Promoting, and Resetting (2004, background): “Arabidopsis vernalization-responsive mutants and accessions that show a strong vernalization requirement have increased FLC RNA and protein levels, whereas vernalized plants have reduced FLC levels (Sheldon et al., 2000b; Michaels and Amasino, 2001; Rouse et al., 2002).”