Effects of particle size and surface coating on cellular uptake of polymeric nanoparticles for oral delivery of anticancer drugs.
By K. Y. Win, S. Feng. Biomaterials, 2005
1,411 citations recorded by the source corpus.
Subfields: Biomaterials, Pharmaceutical Science
View Paper: https://www.semanticscholar.org/paper/a93835c6d56a296aacfa829a5a4159b40348ecc9
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In Biomaterials
In Pharmaceutical Science
Citations in the corpus
- Nanomaterial cytotoxicity is composition, size, and cell type dependent (2010, background): “This may be due to intracellular mechanisms which restrict continuous nanoparticle uptake due to saturation [71-73].”
- Endocytosis and exocytosis of nanoparticles in mammalian cells (2014, methodology): “The cellular uptake of polystyrene (PS) nanoparticles of various sizes was also tested on a human colon adenocarcinoma cell line.(25) The PS nanoparticles with a size of 100 nm were taken up into the cells more efficiently than those with sizes of 50, 200, 500, and 1,000 nm.”
- Effect of Zeta Potential on the Properties of Nano-Drug Delivery Systems - A Review (Part 2) (2013, background): “The adsorption of the negatively charged particles at the positively charged sites via electrostatic interaction can lead to localized neutralization and a subsequent bending of the membrane favoring in turn endocytosis for cellular uptake [30].”
- Control of Polymeric Nanoparticle Size to Improve Therapeutic Delivery (2015, background): “uptake was found for the 1-μm particles, but none for the 3-μm particles [104], due to easier uptake of smaller by small intestine epithelium than larger NPs through para- and transepithelial transport [105].”
- Effects of particle size and surface charge on cellular uptake and biodistribution of polymeric nanoparticles. (2010, methodology): “Particle size and surface charge can affect the efficiency and pathway of cellular uptake for liposomes [4], quantum dots [5], polymeric NPs [6,7], gold NPs [8], and silica NPs [2] by influencing the adhesion of the particles and their interaction with cells [9].”
- The role of surface charge in cellular uptake and cytotoxicity of medical nanoparticles (2012, neutral): “Enterocytes are an exception to this rule, because they preferentially ingest particles in the range between 100 and 200 nm.(113) Phagocytic cells, by contrast, preferentially ingest particles between 2 and 3 μm,(114) and phagocytose NPs to a lower extent.”