Endocytosis and exocytosis of nanoparticles in mammalian cells
By Nuri Oh, Ji-Ho Park. International Journal of Nanomedicine, 2014
1,043 citations recorded by the source corpus.
Engineered nanoparticles that can be injected into the human body hold tremendous potential to detect and treat complex diseases. Understanding of the endocytosis and exocytosis mechanisms of nanoparticles is essential for safe and efficient therapeutic application. In particular, exocytosis is of significance in the removal of nanoparticles with drugs and contrast agents from the body, while endocytosis is of great importance for the targeting of nanoparticles in disease sites. Here, we review the recent research on the endocytosis and exocytosis of functionalized nanoparticles based on various sizes, shapes, and surface chemistries. We believe that this review contributes to the design of safe nanoparticles that can efficiently enter and leave human cells and tissues.
Subfields: Biomaterials, Electronic, Optical and Magnetic Materials, Materials Chemistry
View Paper: https://www.semanticscholar.org/paper/64ed9c86fb87c1e7e530f598b923af362906f69f
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In Biomaterials
Citations in the corpus
- Brief update on endocytosis of nanomedicines (2019, background): “A majority of nanoparticles residing in the endo/lysosomal system are also ejected out of the cell, further contributing to a decrease in efficacy [9,10].”