Pyrrolysine Encoded by UAG in Archaea: Charging of a UAG-Decoding Specialized tRNA

By G. Srinivasan, Carey M. James, J. Krzycki. Science, 2002

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Gelatinase-mediated migration and invasion of cancer cells. (2005, background): “It is also conceivable that the other noncanonical proteinogenic amino acid, pyrrolysine, could be similarly incorporated into phage particles (Namy et al., 2004; Srinivasan et al., 2002).”
On the origins of cells: a hypothesis for the evolutionary transitions from abiotic geochemistry to chemoautotrophic prokaryotes, and from prokaryotes to nucleated cells. (2003, background): “…aqueous environment is even more strictly conserved than the universal genetic code, because there are rare deviations from the universal code (Hao et al. 2002; Srinivasan et al. 2002), but there are no exceptions whatsoever to the principle of semi-permeable compartmentation from the environment.”
Query-Dependent Banding (QDB) for Faster RNA Similarity Searches (2007, methodology): “The state of the art in large-scale transfer RNA gene identification remains the CM-based program tRNAscan-SE [1], and CMs were also used, for example, to discover the divergent tRNA for pyrrolysine, the ‘‘22nd amino acid’’ [40].”