Interacting molecular loops in the mammalian circadian clock.

By L. Shearman, Sathya R. Sriram, D. Weaver, E. Maywood, I. Chaves, B. Zheng, K. Kume, Cheng Chi Lee, van der Horst Gt, M. Hastings and 1 more. Science, 2000

1,405 citations recorded by the source corpus.

Subfields: Endocrine and Autonomic Systems, Plant Science

View Paper: https://www.semanticscholar.org/paper/a8c1f29e9385756e87a1e289947841ea96036f37

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Endocrine and Autonomic Systems

In Plant Science

Citations in the corpus

microRNA modulation of circadian-clock period and entrainment. (2007, neutral): “(2002); U = Ueda et al. (2002). c Microarray analysis of light-inducible genes in the SCN: Araki et al.”
The circadian gene per1 plays an important role in cell growth and DNA damage control in human cancer cells. (2006, background): “In mammals, the circadian system is composed of a central pacemaker located in the hypothalamus and local oscillators in the peripheral tissues (Shearman et al., 2000; Reppert and Weaver, 2002; Schibler and Sassone-Corsi, 2002).”
Differential functions of mPer1, mPer2, and mPer3 in the SCN circadian clock. (2001, methodology): “…Reduced levels compared to wild-type controls. no D, No change compared to wild-type mice. a Data from Zheng et al., 1999. b Data from Shearman et al., 2000b. c Data from Shearman et al., 2000a. 6 (corresponding to amino acid residues A148–V234 of GenBank PCR genotyping for mPer2…”
Circadian rhythm disturbances in depression (2008, background): “, 1985), and more recently in the mammalian brain (Gekakis et al., 1998; Hastings et al., 2007; King et al., 1997; Shearman et al., 2000; Tei et al., 1997; Vitaterna et al., 1994).”
Physiology of circadian entrainment. (2010, background): “Casein kinases regulate PER1/2 and CRY1/2 proteins accumulation and degradation metabolism, as well as the activity of BMAL1; in addition, phosphorylation chaperones dimeric combinations of these proteins into the nucleus to regulate mper and mcry transcription (119, 375, 412, 433).”
Functional consequences of a CKIδ mutation causing familial advanced sleep phase syndrome (2005, background): “Precise control of the mammalian clock requires careful regulation of clock protein production, post-translational modifications and protein–protein interaction”
Nonredundant roles of the mPer1 and mPer2 genes in the mammalian circadian clock. (2001, background): “In contrast, mPer3 knockout mice have anCollege of Cornell University, 1300 York Avenue, New York, New essentially normal clock (Shearman et al., 2000a).”