A pilot toxicology study of single-walled carbon nanotubes in a small sample of mice.

By M. Schipper, Nozomi Nakayama-Ratchford, C. Davis, N. W. Kam, Pauline Chu, Zhuang Liu, Xiaoming Sun, Hongjie Dai, Sanjiv Sam Gambhir. Nature Nanotechnology, 2008

749 citations recorded by the source corpus.

Subfields: Biomedical Engineering, Materials Chemistry

View Paper: https://www.semanticscholar.org/paper/7d39cbc30e9917bd9dd85329a8a7013a84841817

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Biomedical Engineering

1. Zhuang Liu
2. Hongjie Dai
3. Kostas Kostarelos
4. M. Prato
5. A. Bianco
6. Xiaoyuan Chen
7. Kai Yang
8. S. Sherlock

In Materials Chemistry

1. Zhuang Liu
2. Kostas Kostarelos
3. Hongjie Dai
4. M. Prato
5. A. Bianco
6. Kai Yang
7. Xiaoyuan Chen
8. S. Sherlock

Citations in the corpus

• Carbon nanotubes as photoacoustic molecular imaging agents in living mice (2008, neutral): “Such nano-therapeutic and cancer imaging applications would gain further clinical interest as single-walled carbon nanotubes continue to show no toxic effect”
• The effect of nanoparticle size, shape, and surface chemistry on biological systems. (2012, background): “The differential toxicity may be related to a localized concentration of nanoparticles (46).”
• Golden carbon nanotubes as multimodal photoacoustic and photothermal high-contrast molecular agents. (2009, background): “The clinical relevance of carbon nanotubes, however, has been under debate because of concerns over their toxicity, although there are differences in opinions among investigator”
• Promises, facts and challenges for carbon nanotubes in imaging and therapeutics. (2009, background): “; 2) the liver is the predominant organ where coated nanotubes tended to accumulat”
• The journey of a drug-carrier in the body: an anatomo-physiological perspective. (2012, neutral): “5 nm [102,103], and carbon nanotubes [104,105].”
• Contrast agents for molecular photoacoustic imaging (2016, background): “Several studies have reported cytotoxicity and inflammatory potential of SWNTs(92,93), although this can be significantly reduced by functionalization.(94,95) On the contrary, emerging evidence suggests that nanodiamonds exhibit high biocompatibility(96,97,98).”
• Drug delivery with carbon nanotubes for in vivo cancer treatment (2008, methodology): “ delivery for effective cancer treatment with low side effects. More importantly, our water-soluble SWNT-PTX formulation is cremophor free. SWNTs have been proved to be safe at least in mouse models. (21, 22) The amount of SWNTs required to give 5mg/kg of PTX is only ~4mg/kg, compared with ~420mg/kg”
• Targeted killing of cancer cells in vivo and in vitro with EGF-directed carbon nanotube-based drug delivery. (2009, background): “The biodistribution profile of our nanotube bioconjugates showed accumulation in different vital organs as also reported for nanotubes solubilized with PEG.(23,29)”
• In vivo pharmacokinetics, long-term biodistribution, and toxicology of PEGylated graphene in mice. (2011, background): “Similar black spots or pigments were observed before in the liver of mice injected with carbon nanotubes.(6,34) We counted the total numbers of black spots over large image fields and plotted the averaged spot numbers per field against the time (Figure 2f).”