Magnetofection: enhancing and targeting gene delivery by magnetic force in vitro and in vivo

By Franz Scherer, M. Anton, U. Schillinger, J. Henke, C. Bergemann, A. Krüger, B. Gansbacher, C. Plank. Gene Therapy, 2002

925 citations recorded by the source corpus.

Subfields: Genetics, Infectious Diseases, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/a8aab46c546366cd38a4863cc52a577fde0896e0

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Citations in the corpus

Mammalian cell transfection: the present and the future (2010, methodology): “In addition to those mentioned above, there are other physical methods using ultrasound (sonoporation) and magnetic field (magnetofection) [23–25].”
Synthesis and surface engineering of iron oxide nanoparticles for biomedical applications. (2005, background): “Further, since these magnetic particles do not rely on receptors or other cell membrane-bound proteins for cell uptake, it is possible to transfect cells that normally are non-permissive [239].”
Magnetic nanoparticles for gene and drug delivery (2008, positive): “Polyethyleneimine-coated magnetic particles were ﬁ rst reported by Scherer et al in 2002 (Scherer et al 2002) and provided the ﬁ rst example of in vitro magnetic nanoparticle-mediated non-viral gene delivery.”
Nanoparticles in tissue engineering: applications, challenges and prospects (2018, background): “108 Furthermore, in endothelial cells 109 and embryonic stem cells, 110 which are generally resistant to traditional transfection methods, mag-netofection showed high expression levels in target cells.”
Progress in applications of magnetic nanoparticles in biomedicine (2009, background): “Since 2000, when Mah et al [14, 15] first described magnetic microand nanoparticle-based gene transfection (in vitro) by linking viral vectors to magnetic carriers, there has been a dramatic expansion of work aimed at adapting this technique for nonviral transfection of DNA, siRNA and other biomolec”
Magnetic nanoparticles in MR imaging and drug delivery. (2008, background): “The use of MNPs as carriers for antisense oligodioxynucleotides (ODNs) or gene vectors overcomes many of the problems associated with the delivery of these therapeutic agents [195,196].”
Nanotoxicity of iron oxide nanoparticle internalization in growing neurons. (2007, background): “Targeted delivery is used to deliver drugs or genes regio-specifically by attaching them to MNPs and locally concentrating the resulting complexes in vivo to the desired locale [5,6].”
Viral and nonviral delivery systems for gene delivery (2012, background): “These nanomeric complexes are generally stable enough to produce their bound nucleic acids from degradation and are competent to enter cells usually by endocytosis.[112] Cationic nonviral delivery systems have several advantages compared to other nonviral systems and especially viral vectors, such a”
Tuning the properties of magnetic nanowires (2006, neutral): “[9, 10].”