The evolutionary history of methicillin-resistant Staphylococcus aureus (MRSA)

By M. Enright, D. Robinson, Gaynor A. Randle, E. Feil, H. Grundmann, B. Spratt, C. Walsh. Proceedings of the National Academy of Sciences of the United States of America, 2002

1,762 citations recorded by the source corpus.

Subfields: Genetics, Infectious Diseases, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/a893973146111d26accfc79e555267227371169e

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Citations in the corpus

Fungal endophytes and bioprospecting (2009, background): “The urgent need to discover novel chemicals with therapeutic properties is underscored by the evolution of drug resistant pathogens and the need for less toxic drugs (e.g. Anderson 2005; Enright et al. 2002).”
Waves of resistance: Staphylococcus aureus in the antibiotic era (2009, background): “) and other, highly successful MRSA lineages emerge”
Ancient Origin and Gene Mosaicism of the Progenitor of Mycobacterium tuberculosis (2005, background): “The mean synonymous distance among distinct alleles in the tubercle bacilli (0.0083–0.039) was similar to that observed in many bacterial species known to be diverse, such as Staphylococcus aureus (0.023–0.037) [4,5, 20 ].”
The evolution of Staphylococcus aureus. (2008, background): “However, several studies support the multi-clone theory, and it is currently suggested that the SCCmec element was introduced several times into different S aureus lineages (Musser and Kapur, 1992; Fitzgerald et al., 2001; Enright et al., 2002; Qi et al., 2005; Gomes et al., 2006).”
Synergism between natural products and antibiotics against infectious diseases. (2008, background): “aureus acquires resistance to all penicillins and cephalosporins with the acquisition of the gene mecA (Enright et al., 2002), which is carried on a large genetic element called the staphylococcal cassette chromosome mec (SCC mec).”
eBURST: Inferring Patterns of Evolutionary Descent among Clusters of Related Bacterial Genotypes from Multilocus Sequence Typing Data (2004, methodology): “An extensive MLST data set is available for global collections of MRSA isolates, and the BURST algorithm was previously used to determine the origins of MRSA clones from their antibiotic-sensitive forebears (11).”
Community-Associated Methicillin-Resistant Staphylococcus aureus: Epidemiology and Clinical Consequences of an Emerging Epidemic (2010, background): “aureus phage type 83A (subsequently identified to be sequence type 250 [ST250]); this so-called “archaic clone” gradually became infrequent and was replaced in the 1970s and 1980s by five prevalent clonal lineages (10, 267, 771), although many MRSA backgrounds existed between the 1960s and 2000 (999”
Pathogenesis of methicillin-resistant Staphylococcus aureus infection. (2008, background): “Clone namea Clonal complex Other names of cloneb ST1-MRSA-IV 1 USA400, MW2 ST5-MRSA-I 5 UK EMRSA-3 ST5-MRSA-II 5 New York/Japanese, GISA, and USA100 ST5-MRSA-IV 5 USA800 and Pediatric ST228-MRSA-I 5 Southern Germany ST8-MRSA-II 8 Irish-1 ST8-MRSA-IV 8 UK EMRSA-2, -6, USA300, and USA500 ST239-MRSA-II”
Novel Type V Staphylococcal Cassette Chromosome mec Driven by a Novel Cassette Chromosome Recombinase, ccrC (2004, background): “The majority of H-MRSA strains carry one of the three types of SCCmec (type I, II, or III) (6, 16), whereas welldefined American C-MRSA and nonmultiresistant oxacillinresistant S.”
Multi-locus sequence typing: a tool for global epidemiology. (2003, methodology): “Further, when the data are analysed by heuristic techniques, such split decomposition [28] or the BURST (based upon related sequence types) algorithm [ 29 ], these STs occupy a central position, in that they have numerous relatives that appear to be derived from them by a limited number of genetic e”
The molecular evolution of methicillin-resistant Staphylococcus aureus. (2007, methodology): “In contrast to HA-MRSA, CA-MRSA strains are generally susceptible to antibiotics other than b-lactams.”
A Field Guide to Pandemic, Epidemic and Sporadic Clones of Methicillin-Resistant Staphylococcus aureus (2011, neutral): “[220] proposed to designate strains by ‘‘sequence type-MRSA-SCCmec type’’ such as ‘‘ST5-MRSA-II’’.”