Short interfering RNA confers intracellular antiviral immunity in human cells

By Leonid Gitlin, S. Karelsky, Raul Andino. Nature, 2002

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Stable suppression of tumorigenicity by virus-mediated RNA interference. (2002, background): “Parental pRS and pRS-p53 viral stocks were usedinterference (Gitlin et al., 2002; Jacque et al., 2002; Novina et al., for control infections.”
The RNA silencing endonuclease Argonaute 2 mediates specific antiviral immunity in Drosophila melanogaster. (2006, background): “Introduction of artificial dsRNA or siRNAs in insects and mammalian cells elicits an effective antiviral response that protects cells against highly lytic viruses (Gitlin et al. 2002; Li et al. 2002; van Rij and Andino 2006).”
Adipose Tissue Hypoxia in Obesity and Its Impact on Adipocytokine Dysregulation (2007, methodology): “Two pairs of small interfering RNAs (siRNAs) were synthesized chemically by Qiagen, annealed, and transfected into 3T3-L1 adipocytes using Lipofectamine 2000 (Invitrogen) as described previously (27).”
Activation of the interferon system by short-interfering RNAs (2003, background): “This is of critical importance, as siRNAs are currently being explored for their potential therapeutic us”
Gene silencing in mammals by small interfering RNAs (2002, background): “Initial studies to test the potential application of synthetic siRNAs to inhibit virus infection have been promisin”