Senescence‐associated β‐galactosidase is lysosomal β‐galactosidase

By Bo Yun Lee, Jung-A Han, Jun-Sub Im, A. Morrone, K. Johung, E. Goodwin, W. Kleijer, D. DiMaio, E. Hwang. 2006

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DNA damage response and cellular senescence in tissues of aging mice (2009, result): “…activity at pH6 (senescence-associated b-galactosidase or Sen-b-gal; Dimri et al., 1995), which was not causally related to senescence induction (Lee et al., 2006), was cumbersome at least in some tissues and resulted not too seldom in contradictory data (Kurz et al., 2000; Severino et al.,…”
The essence of senescence. (2010, background): “Also, nonsenescent cells display b-galactosidase activity in the lysosomes that functions most optimally at pH 4 (Lee et al. 2006).”
Mechanisms and functions of cellular senescence. (2018, neutral): “This enzymatic activity, which is found in many normal cells under physiological conditions (pH 4.0–4.5), is significantly amplified in senescent cells as a result of increased lysosomal content (96, 97).”
Four faces of cellular senescence (2011, neutral): “(c) Senescent cells express a senescence-associated -galactosidase (SA-Bgal; Dimri et al., 1995), which partly reflects the increase in lysosomal mass (Lee et al., 2006).”
Autophagy mediates the mitotic senescence transition. (2009, background): “One such gene was GLB1, whose product is believed to be responsible for senescenceassociated b-galactosidase (SA-b-gal) activity (Lee et al. 2006).”