Bioconversion of lignocellulose: inhibitors and detoxification

By L. Jönsson, B. Alriksson, N. Nilvebrant. Biotechnology for Biofuels, 2013

1,330 citations recorded by the source corpus.

Bioconversion of lignocellulose by microbial fermentation is typically preceded by an acidic thermochemical pretreatment step designed to facilitate enzymatic hydrolysis of cellulose. Substances formed during the pretreatment of the lignocellulosic feedstock inhibit enzymatic hydrolysis as well as microbial fermentation steps. This review focuses on inhibitors from lignocellulosic feedstocks and how conditioning of slurries and hydrolysates can be used to alleviate inhibition problems. Novel developments in the area include chemical in-situ detoxification by using reducing agents, and methods that improve the performance of both enzymatic and microbial biocatalysts.

Subfields: Biomedical Engineering, Biotechnology, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/a7f135b39bdbfd4e999a3dbf29a732e35df18fab

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Biomedical Engineering

1. Carlos Martín
2. Samet Azman
3. J. V. van Lier
4. L. Jönsson
5. G. Zeeman
6. Ahmad F. Khadem
7. C. Plugge

In Biotechnology

1. Carlos Martín
2. Samet Azman
3. J. V. van Lier
4. L. Jönsson
5. G. Zeeman
6. Ahmad F. Khadem
7. C. Plugge

In Molecular Biology

1. Carlos Martín
2. Antonio Caporusso
3. L. Jönsson
4. A. Capece
5. G. Zeeman
6. I. de Bari

Citations in the corpus

• Oleaginous Yeasts as Cell Factories for the Sustainable Production of Microbial Lipids by the Valorization of Agri-Food Wastes (2021, background): “Although detoxification processes gave interesting results, side effects, such as the increase of production costs and decrease of assimilable sugars, compromise the economic feasibility of the process [114].”
• Pretreatment of lignocellulose: Formation of inhibitory by-products and strategies for minimizing their effects. (2016, positive): “Other possibilities are to use enzymatic treatment, heating and vaporization, liquid– liquid extraction, and liquid–solid extraction (reviewed by Jönsson et al., 2013).”
• Presence and Role of Anaerobic Hydrolytic Microbes in Conversion of Lignocellulosic Biomass for Biogas Production (2015, background): “These by-products include phenolic and aromatic compounds, aliphatic acids, furan aldehydes, and inorganic ions (Jonsson et al., 2013).”