Pretreatment of lignocellulose: Formation of inhibitory by-products and strategies for minimizing their effects.

By L. Jönsson, Carlos Martín. Bioresource Technology, 2016

1,921 citations recorded by the source corpus.

Biochemical conversion of lignocellulosic feedstocks to advanced biofuels and other commodities through a sugar-platform process involves a pretreatment step enhancing the susceptibility of the cellulose to enzymatic hydrolysis. A side effect of pretreatment is formation of lignocellulose-derived by-products that inhibit microbial and enzymatic biocatalysts. This review provides an overview of the formation of inhibitory by-products from lignocellulosic feedstocks as a consequence of using different pretreatment methods and feedstocks as well as an overview of different strategies used to alleviate problems with inhibitors. As technologies for biorefining of lignocellulose become mature and are transferred from laboratory environments to industrial contexts, the importance of management of inhibition problems is envisaged to increase as issues that become increasingly relevant will include the possibility to use recalcitrant feedstocks, obtaining high product yields and high productivity, minimizing the charges of enzymes and microorganisms, and using high solids loadings to obtain high product titers.

Subfields: Biomedical Engineering, Biotechnology, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/d098d547841c1849605ca881a6838fa4cccfac77

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Citations in the corpus

• Acid Hydrolysis of Lignocellulosic Biomass: Sugars and Furfurals Formation (2020, background): “This prevents the onset of cellulose hydrolysis in milder conditions [23].”
• Review on the current status of polymer degradation: a microbial approach (2017, background): “Pretreatment of cellulose material also makes it susceptible to hydrolysis by reducing the barrier [chemical and physical (UV)] effects (Jonsson and Martín 2016; Arutchelvi et al.”
• Microbial production of volatile fatty acids: current status and future perspectives (2017, background): “Microbe engineering to tolerate such inhibitors may be a possible approach (Jönsson and Martı́n 2016).”
• The promising future of microalgae: current status, challenges, and optimization of a sustainable and renewable industry for biofuels, feed, and other products (2018, background): “The next step is the saccharification of the accumulated sugars to monomeric units, as fermenting microorganisms can only convert the fermentable forms of sugars (disaccharides and monosaccharides, usually hexoses and pentoses) into ethanol [104].”
• Laccases as a Potential Tool for the Efficient Conversion of Lignocellulosic Biomass: A Review (2017, background): “of all these inhibitory products is strongly dependent on the feedstock as well as the pretreatment process [23].”