Cutting Edge: The Common γ-Chain Is an Indispensable Subunit of the IL-21 Receptor Complex1

By H. Asao, C. Okuyama, S. Kumaki, N. Ishii, S. Tsuchiya, D. Foster, K. Sugamura. Journal of Immunology, 2001

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Fish Cytokines and Immune Response (2012, background): “Interleukin 21 (IL-21) is a newly recognized member of IL-2 cytokine family that utilizes the common γ-chain receptor subunit for signal transduction [172-174].”
T Follicular Helper Cells Express a Distinctive Transcriptional Profile, Reflecting Their Role as Non-Th1/Th2 Effector Cells That Provide Help for B Cells1 (2004, background): “IL-21 is closely related to IL-2 and IL-15, and receptors for these cytokines share the common -chain (51, 52).”
T follicular helper (TFH) cells in normal and dysregulated immune responses. (2008, background): “The IL-21R consists of a unique cytokine-binding protein (IL-21Rα) and the γc (98, 100), which is also a component of receptor complexes for IL-2, IL-4, IL-7, IL-9, and IL-15 (101).”
Human Lymphoid and Myeloid Cell Development in NOD/LtSz-scid IL2Rγnull Mice Engrafted with Mobilized Human Hemopoietic Stem Cells 12 (2004, background): “This signaling could be mediated through the high affinity IL-2, IL-4, IL-7, IL-9, IL-15, or IL-21 receptors (24, 25).”