AmpC β-Lactamases

By G. Jacoby. Clinical Microbiology Reviews, 2009

1,845 citations recorded by the source corpus.

Subfields: Endocrinology, Molecular Biology, Molecular Medicine

View Paper: https://www.semanticscholar.org/paper/a7841ff9b74cbe1e568f0d43e2d1c6b6526e49f8

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Endocrinology

1. P. Nordmann
2. L. Poirel
3. J. Pitout
4. K. Bush
5. P. Bradford
6. Amy Mathers
7. G. Peirano
8. A. Carattoli

In Molecular Biology

1. L. Poirel
2. P. Nordmann
3. K. Bush
4. J. Pitout
5. S. Gellatly
6. E. Peterson
7. P. Kaur
8. Robert E. W. Hancock

In Molecular Medicine

1. P. Nordmann
2. L. Poirel
3. J. Pitout
4. K. Bush
5. P. Bradford
6. Amy Mathers
7. G. Peirano
8. A. Carattoli

Citations in the corpus

• Klebsiella pneumoniae: a major worldwide source and shuttle for antibiotic resistance (2017, background): “The remarkable versatility of K. pneumoniae to incorporate β-lactamase genes onto transferrable plasmids that enable their spread, gave rise to the emergence and spread of plasmid-mediated AmpC-like cephalosporins in this species (Jacoby 2009; Bush 2010).”
• Antimicrobial Resistance in Escherichia coli (2018, background): “coli, class C β-lactamases, also known as AmpC-type enzymes, confer high-level resistance to those antimicrobial agents (54).”
• Acquired Antibiotic Resistance Genes: An Overview (2011, background): “In addition, plasmidencoded class C β-lactamases or AmpC determinants, like blaCMY have also caught people’s awareness (Jacoby, 2009).”
• Antimicrobial Resistance in Bacteria: Mechanisms, Evolution, and Persistence (2019, background): “…second-, third-generation cephalosporins, aztreonam, and cephamycins but not carbapenems and which are not inhibited by β-lactamase inhibitors) (Jacoby 2009) and carbapenemases (a diverse group of enzymes conferring carbapenem resistance with many conferring resistance to almost all…”
• Pseudomonas aeruginosa: new insights into pathogenesis and host defenses. (2013, background): “The resistance imparted by efflux pumps and AmpC is intricately connected to restricted outer membrane permeability, because the concentration of b-lactams in the periplasm is dependent on the efficiency and rate by which they are transported through the porins of the outer membrane (Jacoby, 2009).”
• The Role of Epidemic Resistance Plasmids and International High-Risk Clones in the Spread of Multidrug-Resistant Enterobacteriaceae (2015, background): “Since high risk clones and epidemic plasmids do not play important roles in the global dissemination of AmpC enzymes, we refer the readers to some excellent review articles on this topic (22-24).”
• Epidemiology of β-Lactamase-Producing Pathogens (2020, background): “Based on DNA sequence homology, the source of plasmid-based ampC genes has been attributed to several genera of bacteria, with a number of AmpC families reported (101).”
• Mechanisms of Antimicrobial Resistance in ESKAPE Pathogens (2016, background): “These bacteria are common causes of life-threatening nosocomial infections amongst critically ill and immunocompromised individuals and are characterized by potential drug resistance mechanisms [5].”
• Antibiotic Resistance Mechanisms in Bacteria: Relationships Between Resistance Determinants of Antibiotic Producers, Environmental Bacteria, and Clinical Pathogens (2018, background): “…indeed suggest that the biological function of β-lactamases may be peptidoglycan recycling (Wiedemann et al., 1998; Macinga and Rather, 1999), although their mobilization to a plasmid results in high expression and high levels of antibiotic resistance (Jacoby, 2009; Dantas and Sommer, 2012).”