The Roles of Osteoprotegerin and Osteoprotegerin Ligand in the Paracrine Regulation of Bone Resorption

By L. Hofbauer, S. Khosla, C. Dunstan, D. Lacey, W. J. Boyle, B. Riggs. Journal of Bone and Mineral Research, 2000

1,205 citations recorded by the source corpus.

Subfields: Molecular Biology, Oncology, Orthopedics and Sports Medicine

View Paper: https://www.semanticscholar.org/paper/a6e6b9fa20fa3eef0cbcc256f9007b74055f7926

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Molecular Biology

1. S. Khosla
2. R. Jilka
3. J. Smolen
4. B. Riggs
5. S. Kousteni
6. S. Manolagas
7. D. Lacey
8. W. J. Boyle

In Oncology

1. S. Khosla
2. S. Manolagas
3. R. Jilka
4. J. Smolen
5. B. Riggs
6. S. Kousteni
7. D. Lacey
8. W. J. Boyle

In Orthopedics and Sports Medicine

1. S. Manolagas
2. D. Lacey
3. W. J. Boyle
4. W. S. Simonet
5. S. Khosla
6. J. Smolen
7. K. Redlich
8. Jay J Cao

Citations in the corpus

• Role of receptor activator of nuclear factor-κB ligand and osteoprotegerin in bone cell biology (2001, background): “cytokines act as the distal effector molecules onto which many growth factors, cytokines, peptide and steroid hormones, and drugs known to affect bone metabolism converge [64].”
• Sex steroids and the construction and conservation of the adult skeleton. (2002, background): “Second, rho appears to be comprised of a cascade of marrow-derived cytokines that include both pro-inflammatory cytokines and the OPG/RANKL/RANK regulatory system.”
• Osteoclast differentiation and activation (2003, background): “Hormones and factors that stimulate bone resorption in vivo induce the expression of RANKL on osteogenic stromal cell”
• Matrix Metalloproteinase 9 and Vascular Endothelial Growth Factor Are Essential for Osteoclast Recruitment into Developing Long Bones (2000, background): “Osteoclasts are generated from hematopoietic stem cells under the control of several systemic and local factors (Hofbauer et al., 2000).”
• Mechanisms of Bone Resorption in Periodontitis (2015, background): “In the presence of periodontopathogens, CD4+ T cells show increased RANKL expression [11, 24, 25, 46, 49].”
• Sex steroids and bone. (2002, background): “In addition, there has been evidence that estrogens stimulate the production of osteoprotegerin (OPG), a potent anti-osteoclastogenic factor.”
• Inflammatory bone loss: pathogenesis and therapeutic intervention (2012, background): “M-CSF-, RANKL- and FOS-deficient animals lack osteoclasts and consequently have an osteopetrotic phenotyp”
• Changes in proinflammatory cytokine activity after menopause. (2002, background): “Although the data are still somewhat conflicting (226, 237, 239, 327), IL-6 also appears to contribute to this up-regulation of RANKL activity in estrogen-deficient osteoblastic cells (318, 328).”
• Role of RANK ligand in mediating increased bone resorption in early postmenopausal women. (2003, background): “In vitro studies have shown that IL-1α, TNF-α, and PGE2 upregulate RANKL (10, 11), and these cytokines have been reported to be increased by estrogen deficiency (1, 3, 4).”